Biallelic, Selectable, Knock-in Targeting of CCR5 via CRISPR-Cas9 Mediated Homology Directed Repair Inhibits HIV-1 Replication

Transplanting HIV-1 positive patients with hematopoietic stem cells homozygous for a 32 bp deletion in the chemokine receptor type 5 (CCR5) gene resulted in a loss of detectable HIV-1, suggesting genetically disrupting CCR5 is a promising approach for HIV-1 cure. Targeting the CCR5-locus with CRISPR...

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Detalles Bibliográficos
Autores principales: Scheller, Stefan H., Rashad, Yasmine, Saleh, Fayez M., Willingham, Kurtis A., Reilich, Antonia, Lin, Dong, Izadpanah, Reza, Alt, Eckhard U., Braun, Stephen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978527/
https://www.ncbi.nlm.nih.gov/pubmed/35386712
http://dx.doi.org/10.3389/fimmu.2022.821190

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