Intracellular Cholesterol Synthesis and Transport

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this revi...

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Detalles Bibliográficos
Autores principales: Shi, Qingyang, Chen, Jiahuan, Zou, Xiaodong, Tang, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978673/
https://www.ncbi.nlm.nih.gov/pubmed/35386193
http://dx.doi.org/10.3389/fcell.2022.819281
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author Shi, Qingyang
Chen, Jiahuan
Zou, Xiaodong
Tang, Xiaochun
author_facet Shi, Qingyang
Chen, Jiahuan
Zou, Xiaodong
Tang, Xiaochun
author_sort Shi, Qingyang
collection PubMed
description Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.
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spelling pubmed-89786732022-04-05 Intracellular Cholesterol Synthesis and Transport Shi, Qingyang Chen, Jiahuan Zou, Xiaodong Tang, Xiaochun Front Cell Dev Biol Cell and Developmental Biology Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8978673/ /pubmed/35386193 http://dx.doi.org/10.3389/fcell.2022.819281 Text en Copyright © 2022 Shi, Chen, Zou and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Shi, Qingyang
Chen, Jiahuan
Zou, Xiaodong
Tang, Xiaochun
Intracellular Cholesterol Synthesis and Transport
title Intracellular Cholesterol Synthesis and Transport
title_full Intracellular Cholesterol Synthesis and Transport
title_fullStr Intracellular Cholesterol Synthesis and Transport
title_full_unstemmed Intracellular Cholesterol Synthesis and Transport
title_short Intracellular Cholesterol Synthesis and Transport
title_sort intracellular cholesterol synthesis and transport
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978673/
https://www.ncbi.nlm.nih.gov/pubmed/35386193
http://dx.doi.org/10.3389/fcell.2022.819281
work_keys_str_mv AT shiqingyang intracellularcholesterolsynthesisandtransport
AT chenjiahuan intracellularcholesterolsynthesisandtransport
AT zouxiaodong intracellularcholesterolsynthesisandtransport
AT tangxiaochun intracellularcholesterolsynthesisandtransport

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