Leveraging the 1,3-azadiene-anhydride reaction for the synthesis of functionalized piperidines bearing up to five contiguous stereocenters

A modular and scalable strategy, which remodels 3-methylglutaric anhydride to 2-oxopiperidines bearing at least three contiguous stereocenters is described. The approach relies on the chemoselective and stereocontrolled annulation of 1,3-azadienes with the anhydride component. The resulting acid-tet...

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Detalles Bibliográficos
Autores principales: Garcia, Jorge, Eichwald, Jane, Zesiger, Jayme, Beng, Timothy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978715/
https://www.ncbi.nlm.nih.gov/pubmed/35424477
http://dx.doi.org/10.1039/d1ra07390g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978715/
https://www.ncbi.nlm.nih.gov/pubmed/35424477
http://dx.doi.org/10.1039/d1ra07390g

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