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Leveraging the 1,3-azadiene-anhydride reaction for the synthesis of functionalized piperidines bearing up to five contiguous stereocenters

A modular and scalable strategy, which remodels 3-methylglutaric anhydride to 2-oxopiperidines bearing at least three contiguous stereocenters is described. The approach relies on the chemoselective and stereocontrolled annulation of 1,3-azadienes with the anhydride component. The resulting acid-tet...

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Detalles Bibliográficos
Autores principales:	Garcia, Jorge, Eichwald, Jane, Zesiger, Jayme, Beng, Timothy K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978715/ https://www.ncbi.nlm.nih.gov/pubmed/35424477 http://dx.doi.org/10.1039/d1ra07390g

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