Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic?

BACKGROUND: Single-cell sequencing studies on the lung microenvironment have revealed that the outcome of COVID-19 depends largely on the immune system response rather than the viral load. A robust innate immune response and a regulated adaptive immunity can prevent the worst outcomes such as hospit...

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Detalles Bibliográficos
Autores principales: AbdelMassih, Antoine, Gaber, Hanya, El Shershaby, Meryam, Hanafy, Maram, Omar, Yasmin, Husseiny, Reem, AlShehry, Nada, Ismail, Habiba-Allah, Kamel, Aya, Hozaien, Rafeef, Khaled, Ghadeer, Amer, Mohamed, Turki, Aya, Fawzy, Heba, Puligheddu, Stefano, Khaled, Dalia, Thabet, Nardine Nasry, Abdelaziz, Mariam Sherif, Barakat, Mustafa, Sharaf, Sara, Mohamed, Ahmed, Mohsen, Dina, El Feky, Amr, Adly, Hadil, Ibrahim, Eman, Mahmoud, Rana, Reda, Mirna, Riad, Felopateer, Vasile, Carmen, Shohdi, Mahitab Adel, Hesham, Nadine, El-Husseiny, Nadine, Ragy, Rana, Fouda, Raghda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978766/
http://dx.doi.org/10.1186/s43054-022-00105-2
Descripción
Sumario:BACKGROUND: Single-cell sequencing studies on the lung microenvironment have revealed that the outcome of COVID-19 depends largely on the immune system response rather than the viral load. A robust innate immune response and a regulated adaptive immunity can prevent the worst outcomes such as hospitalization and the need for mechanical ventilation. MAIN BODY: Intriguingly, several vaccines pertaining to the routine vaccination schedule, not only BCG, can skew the immune response towards the aforementioned beneficial effects. SHORT CONCLUSION: This means that routine immunization not only can help in the current pandemic but can also offer a rapid rescue in the subsequent epidemics or pandemics until a vaccine is developed.

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