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Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic?
BACKGROUND: Single-cell sequencing studies on the lung microenvironment have revealed that the outcome of COVID-19 depends largely on the immune system response rather than the viral load. A robust innate immune response and a regulated adaptive immunity can prevent the worst outcomes such as hospit...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978766/ http://dx.doi.org/10.1186/s43054-022-00105-2 |
| _version_ | 1784681025786347520 |
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| author | AbdelMassih, Antoine Gaber, Hanya El Shershaby, Meryam Hanafy, Maram Omar, Yasmin Husseiny, Reem AlShehry, Nada Ismail, Habiba-Allah Kamel, Aya Hozaien, Rafeef Khaled, Ghadeer Amer, Mohamed Turki, Aya Fawzy, Heba Puligheddu, Stefano Khaled, Dalia Thabet, Nardine Nasry Abdelaziz, Mariam Sherif Barakat, Mustafa Sharaf, Sara Mohamed, Ahmed Mohsen, Dina El Feky, Amr Adly, Hadil Ibrahim, Eman Mahmoud, Rana Reda, Mirna Riad, Felopateer Vasile, Carmen Shohdi, Mahitab Adel Hesham, Nadine El-Husseiny, Nadine Ragy, Rana Fouda, Raghda |
| author_facet | AbdelMassih, Antoine Gaber, Hanya El Shershaby, Meryam Hanafy, Maram Omar, Yasmin Husseiny, Reem AlShehry, Nada Ismail, Habiba-Allah Kamel, Aya Hozaien, Rafeef Khaled, Ghadeer Amer, Mohamed Turki, Aya Fawzy, Heba Puligheddu, Stefano Khaled, Dalia Thabet, Nardine Nasry Abdelaziz, Mariam Sherif Barakat, Mustafa Sharaf, Sara Mohamed, Ahmed Mohsen, Dina El Feky, Amr Adly, Hadil Ibrahim, Eman Mahmoud, Rana Reda, Mirna Riad, Felopateer Vasile, Carmen Shohdi, Mahitab Adel Hesham, Nadine El-Husseiny, Nadine Ragy, Rana Fouda, Raghda |
| author_sort | AbdelMassih, Antoine |
| collection | PubMed |
| description | BACKGROUND: Single-cell sequencing studies on the lung microenvironment have revealed that the outcome of COVID-19 depends largely on the immune system response rather than the viral load. A robust innate immune response and a regulated adaptive immunity can prevent the worst outcomes such as hospitalization and the need for mechanical ventilation. MAIN BODY: Intriguingly, several vaccines pertaining to the routine vaccination schedule, not only BCG, can skew the immune response towards the aforementioned beneficial effects. SHORT CONCLUSION: This means that routine immunization not only can help in the current pandemic but can also offer a rapid rescue in the subsequent epidemics or pandemics until a vaccine is developed. |
| format | Online Article Text |
| id | pubmed-8978766 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89787662022-04-05 Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? AbdelMassih, Antoine Gaber, Hanya El Shershaby, Meryam Hanafy, Maram Omar, Yasmin Husseiny, Reem AlShehry, Nada Ismail, Habiba-Allah Kamel, Aya Hozaien, Rafeef Khaled, Ghadeer Amer, Mohamed Turki, Aya Fawzy, Heba Puligheddu, Stefano Khaled, Dalia Thabet, Nardine Nasry Abdelaziz, Mariam Sherif Barakat, Mustafa Sharaf, Sara Mohamed, Ahmed Mohsen, Dina El Feky, Amr Adly, Hadil Ibrahim, Eman Mahmoud, Rana Reda, Mirna Riad, Felopateer Vasile, Carmen Shohdi, Mahitab Adel Hesham, Nadine El-Husseiny, Nadine Ragy, Rana Fouda, Raghda Egypt Pediatric Association Gaz Review BACKGROUND: Single-cell sequencing studies on the lung microenvironment have revealed that the outcome of COVID-19 depends largely on the immune system response rather than the viral load. A robust innate immune response and a regulated adaptive immunity can prevent the worst outcomes such as hospitalization and the need for mechanical ventilation. MAIN BODY: Intriguingly, several vaccines pertaining to the routine vaccination schedule, not only BCG, can skew the immune response towards the aforementioned beneficial effects. SHORT CONCLUSION: This means that routine immunization not only can help in the current pandemic but can also offer a rapid rescue in the subsequent epidemics or pandemics until a vaccine is developed. Springer Berlin Heidelberg 2022-04-04 2022 /pmc/articles/PMC8978766/ http://dx.doi.org/10.1186/s43054-022-00105-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Review AbdelMassih, Antoine Gaber, Hanya El Shershaby, Meryam Hanafy, Maram Omar, Yasmin Husseiny, Reem AlShehry, Nada Ismail, Habiba-Allah Kamel, Aya Hozaien, Rafeef Khaled, Ghadeer Amer, Mohamed Turki, Aya Fawzy, Heba Puligheddu, Stefano Khaled, Dalia Thabet, Nardine Nasry Abdelaziz, Mariam Sherif Barakat, Mustafa Sharaf, Sara Mohamed, Ahmed Mohsen, Dina El Feky, Amr Adly, Hadil Ibrahim, Eman Mahmoud, Rana Reda, Mirna Riad, Felopateer Vasile, Carmen Shohdi, Mahitab Adel Hesham, Nadine El-Husseiny, Nadine Ragy, Rana Fouda, Raghda Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? |
| title | Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? |
| title_full | Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? |
| title_fullStr | Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? |
| title_full_unstemmed | Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? |
| title_short | Learned lesson from COVID-19: can routine immunizations be the first line of defense against the next pandemic? |
| title_sort | learned lesson from covid-19: can routine immunizations be the first line of defense against the next pandemic? |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978766/ http://dx.doi.org/10.1186/s43054-022-00105-2 |
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