Proposal of a population wide genome-based testing for Covid-19

Our lives (and deaths) have by now been dominated for two years by COVID-19, a pandemic that has caused hundreds of millions of disease cases, millions of deaths, trillions in economic costs, and major restrictions on our freedom. Here we suggest a novel tool for controlling the COVID-19 pandemic. T...

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Autores principales: Lehrach, Hans, Curtis, Jon, Lange, Bodo, Ogilvie, Lesley A., Gauss, Richard, Steininger, Christoph, Scholz, Erhard, Kreck, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978767/
https://www.ncbi.nlm.nih.gov/pubmed/35379812
http://dx.doi.org/10.1038/s41598-022-08934-2
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author Lehrach, Hans
Curtis, Jon
Lange, Bodo
Ogilvie, Lesley A.
Gauss, Richard
Steininger, Christoph
Scholz, Erhard
Kreck, Matthias
author_facet Lehrach, Hans
Curtis, Jon
Lange, Bodo
Ogilvie, Lesley A.
Gauss, Richard
Steininger, Christoph
Scholz, Erhard
Kreck, Matthias
author_sort Lehrach, Hans
collection PubMed
description Our lives (and deaths) have by now been dominated for two years by COVID-19, a pandemic that has caused hundreds of millions of disease cases, millions of deaths, trillions in economic costs, and major restrictions on our freedom. Here we suggest a novel tool for controlling the COVID-19 pandemic. The key element is a method for a population-scale PCR-based testing, applied on a systematic and repeated basis. For this we have developed a low cost, highly sensitive virus-genome-based test. Using Germany as an example, we demonstrate by using a mathematical model, how useful this strategy could have been in controlling the pandemic. We show using real-world examples how this might be implemented on a mass scale and discuss the feasibility of this approach.
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spelling pubmed-89787672022-04-05 Proposal of a population wide genome-based testing for Covid-19 Lehrach, Hans Curtis, Jon Lange, Bodo Ogilvie, Lesley A. Gauss, Richard Steininger, Christoph Scholz, Erhard Kreck, Matthias Sci Rep Article Our lives (and deaths) have by now been dominated for two years by COVID-19, a pandemic that has caused hundreds of millions of disease cases, millions of deaths, trillions in economic costs, and major restrictions on our freedom. Here we suggest a novel tool for controlling the COVID-19 pandemic. The key element is a method for a population-scale PCR-based testing, applied on a systematic and repeated basis. For this we have developed a low cost, highly sensitive virus-genome-based test. Using Germany as an example, we demonstrate by using a mathematical model, how useful this strategy could have been in controlling the pandemic. We show using real-world examples how this might be implemented on a mass scale and discuss the feasibility of this approach. Nature Publishing Group UK 2022-04-04 /pmc/articles/PMC8978767/ /pubmed/35379812 http://dx.doi.org/10.1038/s41598-022-08934-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lehrach, Hans
Curtis, Jon
Lange, Bodo
Ogilvie, Lesley A.
Gauss, Richard
Steininger, Christoph
Scholz, Erhard
Kreck, Matthias
Proposal of a population wide genome-based testing for Covid-19
title Proposal of a population wide genome-based testing for Covid-19
title_full Proposal of a population wide genome-based testing for Covid-19
title_fullStr Proposal of a population wide genome-based testing for Covid-19
title_full_unstemmed Proposal of a population wide genome-based testing for Covid-19
title_short Proposal of a population wide genome-based testing for Covid-19
title_sort proposal of a population wide genome-based testing for covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978767/
https://www.ncbi.nlm.nih.gov/pubmed/35379812
http://dx.doi.org/10.1038/s41598-022-08934-2
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