Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report

Several cases of pigmented mammary Paget’s disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mam...

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Autores principales: Rao, Shijia, Wang, Alun, Liu, Wei, Yin, Hongling, Li, Ji, Tsang, Lemuel Shui-Lun, Wu, Yuhui, Shi, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978827/
https://www.ncbi.nlm.nih.gov/pubmed/35386919
http://dx.doi.org/10.3389/fmed.2022.839954
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author Rao, Shijia
Wang, Alun
Liu, Wei
Yin, Hongling
Li, Ji
Tsang, Lemuel Shui-Lun
Wu, Yuhui
Shi, Wei
author_facet Rao, Shijia
Wang, Alun
Liu, Wei
Yin, Hongling
Li, Ji
Tsang, Lemuel Shui-Lun
Wu, Yuhui
Shi, Wei
author_sort Rao, Shijia
collection PubMed
description Several cases of pigmented mammary Paget’s disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma in situ due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease.
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spelling pubmed-89788272022-04-05 Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report Rao, Shijia Wang, Alun Liu, Wei Yin, Hongling Li, Ji Tsang, Lemuel Shui-Lun Wu, Yuhui Shi, Wei Front Med (Lausanne) Medicine Several cases of pigmented mammary Paget’s disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma in situ due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8978827/ /pubmed/35386919 http://dx.doi.org/10.3389/fmed.2022.839954 Text en Copyright © 2022 Rao, Wang, Liu, Yin, Li, Tsang, Wu and Shi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Rao, Shijia
Wang, Alun
Liu, Wei
Yin, Hongling
Li, Ji
Tsang, Lemuel Shui-Lun
Wu, Yuhui
Shi, Wei
Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
title Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
title_full Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
title_fullStr Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
title_full_unstemmed Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
title_short Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
title_sort mammary paget disease with melanocytic proliferation mimicking malignant melanoma in situ: a case report
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978827/
https://www.ncbi.nlm.nih.gov/pubmed/35386919
http://dx.doi.org/10.3389/fmed.2022.839954
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