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Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives

In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were readily prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives through the one-pot four-component reaction of malononitrile, cyclo...

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Autores principales: Ghasemi-Ghahsareh, Aref, Safaei-Ghomi, Javad, Oboudatian, Hourieh Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978968/
https://www.ncbi.nlm.nih.gov/pubmed/35425168
http://dx.doi.org/10.1039/d1ra07654j
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author Ghasemi-Ghahsareh, Aref
Safaei-Ghomi, Javad
Oboudatian, Hourieh Sadat
author_facet Ghasemi-Ghahsareh, Aref
Safaei-Ghomi, Javad
Oboudatian, Hourieh Sadat
author_sort Ghasemi-Ghahsareh, Aref
collection PubMed
description In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were readily prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives through the one-pot four-component reaction of malononitrile, cyclohexanone, aromatic aldehydes, and 1,3-indandione. This novel magnetic nanocatalyst was confirmed to be effective and provide products in moderate to excellent yields under reflux conditions. The structure of obtained nanoparticles was characterized using FT-IR, XRD, VSM, EDX, elemental mapping, FE-SEM, and TGA. This synthetic protocol provides several benefits such as excellent yields in short reaction times (64–91%), saving costs, reusability of the catalyst using an external magnet (seven runs), and low catalyst loading.
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spelling pubmed-89789682022-04-13 Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives Ghasemi-Ghahsareh, Aref Safaei-Ghomi, Javad Oboudatian, Hourieh Sadat RSC Adv Chemistry In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were readily prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives through the one-pot four-component reaction of malononitrile, cyclohexanone, aromatic aldehydes, and 1,3-indandione. This novel magnetic nanocatalyst was confirmed to be effective and provide products in moderate to excellent yields under reflux conditions. The structure of obtained nanoparticles was characterized using FT-IR, XRD, VSM, EDX, elemental mapping, FE-SEM, and TGA. This synthetic protocol provides several benefits such as excellent yields in short reaction times (64–91%), saving costs, reusability of the catalyst using an external magnet (seven runs), and low catalyst loading. The Royal Society of Chemistry 2022-01-05 /pmc/articles/PMC8978968/ /pubmed/35425168 http://dx.doi.org/10.1039/d1ra07654j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ghasemi-Ghahsareh, Aref
Safaei-Ghomi, Javad
Oboudatian, Hourieh Sadat
Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
title Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
title_full Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
title_fullStr Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
title_full_unstemmed Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
title_short Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
title_sort supported l-tryptophan on fe(3)o(4)@sio(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978968/
https://www.ncbi.nlm.nih.gov/pubmed/35425168
http://dx.doi.org/10.1039/d1ra07654j
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