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Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives
In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were readily prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives through the one-pot four-component reaction of malononitrile, cyclo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978968/ https://www.ncbi.nlm.nih.gov/pubmed/35425168 http://dx.doi.org/10.1039/d1ra07654j |
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author | Ghasemi-Ghahsareh, Aref Safaei-Ghomi, Javad Oboudatian, Hourieh Sadat |
author_facet | Ghasemi-Ghahsareh, Aref Safaei-Ghomi, Javad Oboudatian, Hourieh Sadat |
author_sort | Ghasemi-Ghahsareh, Aref |
collection | PubMed |
description | In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were readily prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives through the one-pot four-component reaction of malononitrile, cyclohexanone, aromatic aldehydes, and 1,3-indandione. This novel magnetic nanocatalyst was confirmed to be effective and provide products in moderate to excellent yields under reflux conditions. The structure of obtained nanoparticles was characterized using FT-IR, XRD, VSM, EDX, elemental mapping, FE-SEM, and TGA. This synthetic protocol provides several benefits such as excellent yields in short reaction times (64–91%), saving costs, reusability of the catalyst using an external magnet (seven runs), and low catalyst loading. |
format | Online Article Text |
id | pubmed-8978968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-89789682022-04-13 Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives Ghasemi-Ghahsareh, Aref Safaei-Ghomi, Javad Oboudatian, Hourieh Sadat RSC Adv Chemistry In this work, l-tryptophan functionalized silica-coated magnetic nanoparticles were readily prepared and evaluated as a recyclable magnetic nanocatalyst for the synthesis of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives through the one-pot four-component reaction of malononitrile, cyclohexanone, aromatic aldehydes, and 1,3-indandione. This novel magnetic nanocatalyst was confirmed to be effective and provide products in moderate to excellent yields under reflux conditions. The structure of obtained nanoparticles was characterized using FT-IR, XRD, VSM, EDX, elemental mapping, FE-SEM, and TGA. This synthetic protocol provides several benefits such as excellent yields in short reaction times (64–91%), saving costs, reusability of the catalyst using an external magnet (seven runs), and low catalyst loading. The Royal Society of Chemistry 2022-01-05 /pmc/articles/PMC8978968/ /pubmed/35425168 http://dx.doi.org/10.1039/d1ra07654j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Ghasemi-Ghahsareh, Aref Safaei-Ghomi, Javad Oboudatian, Hourieh Sadat Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
title | Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
title_full | Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
title_fullStr | Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
title_full_unstemmed | Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
title_short | Supported l-tryptophan on Fe(3)O(4)@SiO(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
title_sort | supported l-tryptophan on fe(3)o(4)@sio(2) as an efficient and magnetically separable catalyst for one-pot construction of spiro[indene-2,2′-naphthalene]-4′-carbonitrile derivatives |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978968/ https://www.ncbi.nlm.nih.gov/pubmed/35425168 http://dx.doi.org/10.1039/d1ra07654j |
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