Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure

Tolvaptan is a key drug for patients with heart failure. Here, we present a 92‐year‐old woman, whose PT‐INR/dose increased from 1.74 to 3.30 after warfarin and tolvaptan co‐administration, and resulted in a large cerebral infarction after warfarin dose down. Therefore, the interaction between these...

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Detalles Bibliográficos
Autores principales: Nimura, Satomi, Kitahara, Kanayuki, Ueshima, Kazuyo, Mochizuki, Yasuhide, Momo, Kenji, Shinke, Toshiro, Sasaki, Tadanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978989/
https://www.ncbi.nlm.nih.gov/pubmed/35414910
http://dx.doi.org/10.1002/ccr3.5592
Descripción
Sumario:Tolvaptan is a key drug for patients with heart failure. Here, we present a 92‐year‐old woman, whose PT‐INR/dose increased from 1.74 to 3.30 after warfarin and tolvaptan co‐administration, and resulted in a large cerebral infarction after warfarin dose down. Therefore, the interaction between these two drugs may be clinically significant.

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