Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure

Tolvaptan is a key drug for patients with heart failure. Here, we present a 92‐year‐old woman, whose PT‐INR/dose increased from 1.74 to 3.30 after warfarin and tolvaptan co‐administration, and resulted in a large cerebral infarction after warfarin dose down. Therefore, the interaction between these...

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Autores principales: Nimura, Satomi, Kitahara, Kanayuki, Ueshima, Kazuyo, Mochizuki, Yasuhide, Momo, Kenji, Shinke, Toshiro, Sasaki, Tadanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978989/
https://www.ncbi.nlm.nih.gov/pubmed/35414910
http://dx.doi.org/10.1002/ccr3.5592
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author Nimura, Satomi
Kitahara, Kanayuki
Ueshima, Kazuyo
Mochizuki, Yasuhide
Momo, Kenji
Shinke, Toshiro
Sasaki, Tadanori
author_facet Nimura, Satomi
Kitahara, Kanayuki
Ueshima, Kazuyo
Mochizuki, Yasuhide
Momo, Kenji
Shinke, Toshiro
Sasaki, Tadanori
author_sort Nimura, Satomi
collection PubMed
description Tolvaptan is a key drug for patients with heart failure. Here, we present a 92‐year‐old woman, whose PT‐INR/dose increased from 1.74 to 3.30 after warfarin and tolvaptan co‐administration, and resulted in a large cerebral infarction after warfarin dose down. Therefore, the interaction between these two drugs may be clinically significant.
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spelling pubmed-89789892022-04-11 Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure Nimura, Satomi Kitahara, Kanayuki Ueshima, Kazuyo Mochizuki, Yasuhide Momo, Kenji Shinke, Toshiro Sasaki, Tadanori Clin Case Rep Case Reports Tolvaptan is a key drug for patients with heart failure. Here, we present a 92‐year‐old woman, whose PT‐INR/dose increased from 1.74 to 3.30 after warfarin and tolvaptan co‐administration, and resulted in a large cerebral infarction after warfarin dose down. Therefore, the interaction between these two drugs may be clinically significant. John Wiley and Sons Inc. 2022-04-04 /pmc/articles/PMC8978989/ /pubmed/35414910 http://dx.doi.org/10.1002/ccr3.5592 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Nimura, Satomi
Kitahara, Kanayuki
Ueshima, Kazuyo
Mochizuki, Yasuhide
Momo, Kenji
Shinke, Toshiro
Sasaki, Tadanori
Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
title Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
title_full Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
title_fullStr Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
title_full_unstemmed Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
title_short Potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
title_sort potential drug‐drug interaction between tolvaptan and warfarin in a geriatric patient with heart failure
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978989/
https://www.ncbi.nlm.nih.gov/pubmed/35414910
http://dx.doi.org/10.1002/ccr3.5592
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