Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp(–/–) Mice and Implications for Learning and Memory Deficits

Loss-of-function mutations in the gene that encodes TYRO protein kinase-binding protein (TYROBP) cause Nasu-Hakola disease, a heritable disease resembling Alzheimer’s disease (AD). Methylation of N6 methyl-adenosine (m6A) in mRNA plays essential roles in learning and memory. Aberrant m6A methylation...

Descripción completa

Detalles Bibliográficos
Autores principales: Lv, Zhanyun, Xu, Tongxiao, Li, Ran, Zheng, Dejie, Li, Yanxin, Li, Wei, Yang, Yan, Hao, Yanlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978996/
https://www.ncbi.nlm.nih.gov/pubmed/35386591
http://dx.doi.org/10.3389/fnins.2022.739201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978996/
https://www.ncbi.nlm.nih.gov/pubmed/35386591
http://dx.doi.org/10.3389/fnins.2022.739201

Ejemplares similares