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Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp(–/–) Mice and Implications for Learning and Memory Deficits

Loss-of-function mutations in the gene that encodes TYRO protein kinase-binding protein (TYROBP) cause Nasu-Hakola disease, a heritable disease resembling Alzheimer’s disease (AD). Methylation of N6 methyl-adenosine (m6A) in mRNA plays essential roles in learning and memory. Aberrant m6A methylation...

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Detalles Bibliográficos
Autores principales:	Lv, Zhanyun, Xu, Tongxiao, Li, Ran, Zheng, Dejie, Li, Yanxin, Li, Wei, Yang, Yan, Hao, Yanlei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978996/ https://www.ncbi.nlm.nih.gov/pubmed/35386591 http://dx.doi.org/10.3389/fnins.2022.739201

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