DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles

A mixture DMSO–allyl bromide has been developed as a reagent for an atom economic one-pot N-allylation and aryl bromination under basic conditions. Utilizing this reagent, N-allylation–bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scop...

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Autores principales: Smile, Suresh Snoxma, Novanna, Motakatla, Kannadasan, Sathananthan, Shanmugam, Ponnusamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979011/
https://www.ncbi.nlm.nih.gov/pubmed/35425207
http://dx.doi.org/10.1039/d1ra08588c
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author Smile, Suresh Snoxma
Novanna, Motakatla
Kannadasan, Sathananthan
Shanmugam, Ponnusamy
author_facet Smile, Suresh Snoxma
Novanna, Motakatla
Kannadasan, Sathananthan
Shanmugam, Ponnusamy
author_sort Smile, Suresh Snoxma
collection PubMed
description A mixture DMSO–allyl bromide has been developed as a reagent for an atom economic one-pot N-allylation and aryl bromination under basic conditions. Utilizing this reagent, N-allylation–bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed.
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spelling pubmed-89790112022-04-13 DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles Smile, Suresh Snoxma Novanna, Motakatla Kannadasan, Sathananthan Shanmugam, Ponnusamy RSC Adv Chemistry A mixture DMSO–allyl bromide has been developed as a reagent for an atom economic one-pot N-allylation and aryl bromination under basic conditions. Utilizing this reagent, N-allylation–bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed. The Royal Society of Chemistry 2022-01-12 /pmc/articles/PMC8979011/ /pubmed/35425207 http://dx.doi.org/10.1039/d1ra08588c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Smile, Suresh Snoxma
Novanna, Motakatla
Kannadasan, Sathananthan
Shanmugam, Ponnusamy
DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
title DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
title_full DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
title_fullStr DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
title_full_unstemmed DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
title_short DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
title_sort dmso–allyl bromide: a mild and efficient reagent for atom economic one-pot n-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979011/
https://www.ncbi.nlm.nih.gov/pubmed/35425207
http://dx.doi.org/10.1039/d1ra08588c
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