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Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells

In this work, polymer grafted magnetic graphene oxide (GO–PVP–Fe(3)O(4)) was successfully synthesized for efficient delivery of anticancer drug. Firstly, GO was functionalized with the hydrophilic and biocompatible polymer polyvinylpyrrolidone (PVP) and then grafted with magnetic nanoparticles (Fe(3...

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Autores principales: Matiyani, Monika, Rana, Anita, Pal, Mintu, Rana, Sravendra, Melkani, Anand B., Sahoo, Nanda Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979073/
https://www.ncbi.nlm.nih.gov/pubmed/35425302
http://dx.doi.org/10.1039/d1ra05382e
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author Matiyani, Monika
Rana, Anita
Pal, Mintu
Rana, Sravendra
Melkani, Anand B.
Sahoo, Nanda Gopal
author_facet Matiyani, Monika
Rana, Anita
Pal, Mintu
Rana, Sravendra
Melkani, Anand B.
Sahoo, Nanda Gopal
author_sort Matiyani, Monika
collection PubMed
description In this work, polymer grafted magnetic graphene oxide (GO–PVP–Fe(3)O(4)) was successfully synthesized for efficient delivery of anticancer drug. Firstly, GO was functionalized with the hydrophilic and biocompatible polymer polyvinylpyrrolidone (PVP) and then grafted with magnetic nanoparticles (Fe(3)O(4)) through an easy and effective chemical co-precipitation method. Quercetin (QSR) as an anticancer drug was loaded onto the surface of GO–PVP–Fe(3)O(4)via non-covalent interactions. The drug loading capacity was as high as 1.69 mg mg(−1) and the synthesized magnetic nanocarrier shows pH-responsive controlled release of QSR. The cellular cytotoxicity of the synthesized nanocarrier with and without drugs was investigated in human breast cancer MDA MB 231 cells and their effects compared on non-tumorigenic epithelial HEK 293T cells. These results reveal that the drug loaded GO–PVP–Fe(3)O(4) nanohybrid was found to be more toxic than the free drug towards MDA MB 231 cells and exhibits biocompatibility towards HEK 293T cells. Overall, a smart drug delivery system including polymer grafted magnetic graphene oxide as a pH-responsive potential nanocarrier could be beneficial for targeted drug delivery, controlled by an external magnetic field as an advancement in chemotherapy against cancer.
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spelling pubmed-89790732022-04-13 Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells Matiyani, Monika Rana, Anita Pal, Mintu Rana, Sravendra Melkani, Anand B. Sahoo, Nanda Gopal RSC Adv Chemistry In this work, polymer grafted magnetic graphene oxide (GO–PVP–Fe(3)O(4)) was successfully synthesized for efficient delivery of anticancer drug. Firstly, GO was functionalized with the hydrophilic and biocompatible polymer polyvinylpyrrolidone (PVP) and then grafted with magnetic nanoparticles (Fe(3)O(4)) through an easy and effective chemical co-precipitation method. Quercetin (QSR) as an anticancer drug was loaded onto the surface of GO–PVP–Fe(3)O(4)via non-covalent interactions. The drug loading capacity was as high as 1.69 mg mg(−1) and the synthesized magnetic nanocarrier shows pH-responsive controlled release of QSR. The cellular cytotoxicity of the synthesized nanocarrier with and without drugs was investigated in human breast cancer MDA MB 231 cells and their effects compared on non-tumorigenic epithelial HEK 293T cells. These results reveal that the drug loaded GO–PVP–Fe(3)O(4) nanohybrid was found to be more toxic than the free drug towards MDA MB 231 cells and exhibits biocompatibility towards HEK 293T cells. Overall, a smart drug delivery system including polymer grafted magnetic graphene oxide as a pH-responsive potential nanocarrier could be beneficial for targeted drug delivery, controlled by an external magnetic field as an advancement in chemotherapy against cancer. The Royal Society of Chemistry 2022-01-19 /pmc/articles/PMC8979073/ /pubmed/35425302 http://dx.doi.org/10.1039/d1ra05382e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Matiyani, Monika
Rana, Anita
Pal, Mintu
Rana, Sravendra
Melkani, Anand B.
Sahoo, Nanda Gopal
Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells
title Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells
title_full Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells
title_fullStr Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells
title_full_unstemmed Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells
title_short Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells
title_sort polymer grafted magnetic graphene oxide as a potential nanocarrier for ph-responsive delivery of sparingly soluble quercetin against breast cancer cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979073/
https://www.ncbi.nlm.nih.gov/pubmed/35425302
http://dx.doi.org/10.1039/d1ra05382e
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