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Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor

Phosphodiesterase10A (PDE10A) is a potential therapeutic target for the treatment of several neurodegenerative disorders. Thus, extensive efforts of medicinal chemists have been directed toward developing potent PDE10A inhibitors with minimal side effects. However, PDE10A inhibitors are not approved...

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Detalles Bibliográficos
Autores principales:	Al-Nema, Mayasah, Gaurav, Anand, Lee, Vannajan Sanghiran, Gunasekaran, Baskaran, Lee, Ming Tatt, Okechukwu, Patrick, Nimmanpipug, Piyarat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979230/ https://www.ncbi.nlm.nih.gov/pubmed/35425186 http://dx.doi.org/10.1039/d1ra07649c

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