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Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides

The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp(2)–Csp(3) bond, which...

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Detalles Bibliográficos
Autores principales: Gao, Nanxing, Li, Yanshun, Teng, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979266/
https://www.ncbi.nlm.nih.gov/pubmed/35425390
http://dx.doi.org/10.1039/d2ra00010e
Descripción
Sumario:The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp(2)–Csp(3) bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.