Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides

The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp(2)–Csp(3) bond, which...

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Detalles Bibliográficos
Autores principales: Gao, Nanxing, Li, Yanshun, Teng, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979266/
https://www.ncbi.nlm.nih.gov/pubmed/35425390
http://dx.doi.org/10.1039/d2ra00010e
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author Gao, Nanxing
Li, Yanshun
Teng, Dawei
author_facet Gao, Nanxing
Li, Yanshun
Teng, Dawei
author_sort Gao, Nanxing
collection PubMed
description The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp(2)–Csp(3) bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.
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spelling pubmed-89792662022-04-13 Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides Gao, Nanxing Li, Yanshun Teng, Dawei RSC Adv Chemistry The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp(2)–Csp(3) bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide. The Royal Society of Chemistry 2022-01-26 /pmc/articles/PMC8979266/ /pubmed/35425390 http://dx.doi.org/10.1039/d2ra00010e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Gao, Nanxing
Li, Yanshun
Teng, Dawei
Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
title Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
title_full Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
title_fullStr Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
title_full_unstemmed Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
title_short Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
title_sort nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979266/
https://www.ncbi.nlm.nih.gov/pubmed/35425390
http://dx.doi.org/10.1039/d2ra00010e
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AT liyanshun nickelcatalysedcrosselectrophilecouplingofarylbromidesandprimaryalkylbromides
AT tengdawei nickelcatalysedcrosselectrophilecouplingofarylbromidesandprimaryalkylbromides

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