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Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage

Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed...

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Detalles Bibliográficos
Autores principales:	Rodríguez, Jessica, Pérez-González, Cibrán, Martínez-Calvo, Miguel, Mosquera, Jesús, Mascareñas, José L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979313/ https://www.ncbi.nlm.nih.gov/pubmed/35425354 http://dx.doi.org/10.1039/d1ra09180h

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