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Bone Formation in Pleomorphic Adenoma: A Case Report

Pleomorphic adenoma is a benign tumour with variable cytomorphological and architectural elements. It is the most common salivary gland tumour in children and adults. We report a case of a 32-year-old Malay woman who presented with a slow-growing, painless, firm, and mobile nodule of 1 cm x 1 cm in...

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Autores principales: Gubod, EB Robson, Ramanathan, Anand, Chong Mei Yee, Sherrie, Tilakaratne, Wanninayake M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979320/
https://www.ncbi.nlm.nih.gov/pubmed/35392445
http://dx.doi.org/10.7759/cureus.22868
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author Gubod, EB Robson
Ramanathan, Anand
Chong Mei Yee, Sherrie
Tilakaratne, Wanninayake M
author_facet Gubod, EB Robson
Ramanathan, Anand
Chong Mei Yee, Sherrie
Tilakaratne, Wanninayake M
author_sort Gubod, EB Robson
collection PubMed
description Pleomorphic adenoma is a benign tumour with variable cytomorphological and architectural elements. It is the most common salivary gland tumour in children and adults. We report a case of a 32-year-old Malay woman who presented with a slow-growing, painless, firm, and mobile nodule of 1 cm x 1 cm in size at the angle of her mandible on the right side which could be palpated bimanually. Intraorally, this nodule could be palpated at the retromolar area. On excisional biopsy, this nodule was reported as a pleomorphic adenoma with predominant chondroid stromal elements and a large area of bone formation in the stroma. We discuss the possible pathogenesis, differential diagnosis, and clinical significance of this exceptionally rare phenomenon of bone formation in pleomorphic adenoma in minor salivary glands with the literature review. The clinical significance and relevance on treatment outcome for pleomorphic adenoma with bone formation is currently uncertain as there are only a few cases reported in the literature. A good follow-up study is recommended to assess the clinical significance of pleomorphic adenoma with extensive bone formation.
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spelling pubmed-89793202022-04-06 Bone Formation in Pleomorphic Adenoma: A Case Report Gubod, EB Robson Ramanathan, Anand Chong Mei Yee, Sherrie Tilakaratne, Wanninayake M Cureus Pathology Pleomorphic adenoma is a benign tumour with variable cytomorphological and architectural elements. It is the most common salivary gland tumour in children and adults. We report a case of a 32-year-old Malay woman who presented with a slow-growing, painless, firm, and mobile nodule of 1 cm x 1 cm in size at the angle of her mandible on the right side which could be palpated bimanually. Intraorally, this nodule could be palpated at the retromolar area. On excisional biopsy, this nodule was reported as a pleomorphic adenoma with predominant chondroid stromal elements and a large area of bone formation in the stroma. We discuss the possible pathogenesis, differential diagnosis, and clinical significance of this exceptionally rare phenomenon of bone formation in pleomorphic adenoma in minor salivary glands with the literature review. The clinical significance and relevance on treatment outcome for pleomorphic adenoma with bone formation is currently uncertain as there are only a few cases reported in the literature. A good follow-up study is recommended to assess the clinical significance of pleomorphic adenoma with extensive bone formation. Cureus 2022-03-05 /pmc/articles/PMC8979320/ /pubmed/35392445 http://dx.doi.org/10.7759/cureus.22868 Text en Copyright © 2022, Gubod et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Gubod, EB Robson
Ramanathan, Anand
Chong Mei Yee, Sherrie
Tilakaratne, Wanninayake M
Bone Formation in Pleomorphic Adenoma: A Case Report
title Bone Formation in Pleomorphic Adenoma: A Case Report
title_full Bone Formation in Pleomorphic Adenoma: A Case Report
title_fullStr Bone Formation in Pleomorphic Adenoma: A Case Report
title_full_unstemmed Bone Formation in Pleomorphic Adenoma: A Case Report
title_short Bone Formation in Pleomorphic Adenoma: A Case Report
title_sort bone formation in pleomorphic adenoma: a case report
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979320/
https://www.ncbi.nlm.nih.gov/pubmed/35392445
http://dx.doi.org/10.7759/cureus.22868
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