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Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset

Alzheimer’s disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last...

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Autores principales: Homann, Jan, Osburg, Tim, Ohlei, Olena, Dobricic, Valerija, Deecke, Laura, Bos, Isabelle, Vandenberghe, Rik, Gabel, Silvy, Scheltens, Philip, Teunissen, Charlotte E., Engelborghs, Sebastiaan, Frisoni, Giovanni, Blin, Olivier, Richardson, Jill C., Bordet, Regis, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Clark, Christopher, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Dobson, Richard J. B., Legido-Quigley, Cristina, Sleegers, Kristel, Van Broeckhoven, Christine, Wittig, Michael, Franke, Andre, Lill, Christina M., Blennow, Kaj, Zetterberg, Henrik, Lovestone, Simon, Streffer, Johannes, ten Kate, Mara, Vos, Stephanie J. B., Barkhof, Frederik, Visser, Pieter Jelle, Bertram, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979334/
https://www.ncbi.nlm.nih.gov/pubmed/35386118
http://dx.doi.org/10.3389/fnagi.2022.840651
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author Homann, Jan
Osburg, Tim
Ohlei, Olena
Dobricic, Valerija
Deecke, Laura
Bos, Isabelle
Vandenberghe, Rik
Gabel, Silvy
Scheltens, Philip
Teunissen, Charlotte E.
Engelborghs, Sebastiaan
Frisoni, Giovanni
Blin, Olivier
Richardson, Jill C.
Bordet, Regis
Lleó, Alberto
Alcolea, Daniel
Popp, Julius
Clark, Christopher
Peyratout, Gwendoline
Martinez-Lage, Pablo
Tainta, Mikel
Dobson, Richard J. B.
Legido-Quigley, Cristina
Sleegers, Kristel
Van Broeckhoven, Christine
Wittig, Michael
Franke, Andre
Lill, Christina M.
Blennow, Kaj
Zetterberg, Henrik
Lovestone, Simon
Streffer, Johannes
ten Kate, Mara
Vos, Stephanie J. B.
Barkhof, Frederik
Visser, Pieter Jelle
Bertram, Lars
author_facet Homann, Jan
Osburg, Tim
Ohlei, Olena
Dobricic, Valerija
Deecke, Laura
Bos, Isabelle
Vandenberghe, Rik
Gabel, Silvy
Scheltens, Philip
Teunissen, Charlotte E.
Engelborghs, Sebastiaan
Frisoni, Giovanni
Blin, Olivier
Richardson, Jill C.
Bordet, Regis
Lleó, Alberto
Alcolea, Daniel
Popp, Julius
Clark, Christopher
Peyratout, Gwendoline
Martinez-Lage, Pablo
Tainta, Mikel
Dobson, Richard J. B.
Legido-Quigley, Cristina
Sleegers, Kristel
Van Broeckhoven, Christine
Wittig, Michael
Franke, Andre
Lill, Christina M.
Blennow, Kaj
Zetterberg, Henrik
Lovestone, Simon
Streffer, Johannes
ten Kate, Mara
Vos, Stephanie J. B.
Barkhof, Frederik
Visser, Pieter Jelle
Bertram, Lars
author_sort Homann, Jan
collection PubMed
description Alzheimer’s disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. Most of these GWAS used dichotomized clinical diagnostic status, i.e., case vs. control classification, as outcome phenotypes, without the use of biomarkers. An alternative and potentially more powerful study design is afforded by using quantitative AD-related phenotypes as GWAS outcome traits, an analysis paradigm that we followed in this work. Specifically, we utilized genotype and phenotype data from n = 931 individuals collected under the auspices of the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study to perform a total of 19 separate GWAS analyses. As outcomes we used five magnetic resonance imaging (MRI) traits and seven cognitive performance traits. For the latter, longitudinal data from at least two timepoints were available in addition to cross-sectional assessments at baseline. Our GWAS analyses revealed several genome-wide significant associations for the neuropsychological performance measures, in particular those assayed longitudinally. Among the most noteworthy signals were associations in or near EHBP1 (EH domain binding protein 1; on chromosome 2p15) and CEP112 (centrosomal protein 112; 17q24.1) with delayed recall as well as SMOC2 (SPARC related modular calcium binding 2; 6p27) with immediate recall in a memory performance test. On the X chromosome, which is often excluded in other GWAS, we identified a genome-wide significant signal near IL1RAPL1 (interleukin 1 receptor accessory protein like 1; Xp21.3). While polygenic score (PGS) analyses showed the expected strong associations with SNPs highlighted in relevant previous GWAS on hippocampal volume and cognitive function, they did not show noteworthy associations with recent AD risk GWAS findings. In summary, our study highlights the power of using quantitative endophenotypes as outcome traits in AD-related GWAS analyses and nominates several new loci not previously implicated in cognitive decline.
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spelling pubmed-89793342022-04-05 Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset Homann, Jan Osburg, Tim Ohlei, Olena Dobricic, Valerija Deecke, Laura Bos, Isabelle Vandenberghe, Rik Gabel, Silvy Scheltens, Philip Teunissen, Charlotte E. Engelborghs, Sebastiaan Frisoni, Giovanni Blin, Olivier Richardson, Jill C. Bordet, Regis Lleó, Alberto Alcolea, Daniel Popp, Julius Clark, Christopher Peyratout, Gwendoline Martinez-Lage, Pablo Tainta, Mikel Dobson, Richard J. B. Legido-Quigley, Cristina Sleegers, Kristel Van Broeckhoven, Christine Wittig, Michael Franke, Andre Lill, Christina M. Blennow, Kaj Zetterberg, Henrik Lovestone, Simon Streffer, Johannes ten Kate, Mara Vos, Stephanie J. B. Barkhof, Frederik Visser, Pieter Jelle Bertram, Lars Front Aging Neurosci Aging Neuroscience Alzheimer’s disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. Most of these GWAS used dichotomized clinical diagnostic status, i.e., case vs. control classification, as outcome phenotypes, without the use of biomarkers. An alternative and potentially more powerful study design is afforded by using quantitative AD-related phenotypes as GWAS outcome traits, an analysis paradigm that we followed in this work. Specifically, we utilized genotype and phenotype data from n = 931 individuals collected under the auspices of the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery (EMIF-AD MBD) study to perform a total of 19 separate GWAS analyses. As outcomes we used five magnetic resonance imaging (MRI) traits and seven cognitive performance traits. For the latter, longitudinal data from at least two timepoints were available in addition to cross-sectional assessments at baseline. Our GWAS analyses revealed several genome-wide significant associations for the neuropsychological performance measures, in particular those assayed longitudinally. Among the most noteworthy signals were associations in or near EHBP1 (EH domain binding protein 1; on chromosome 2p15) and CEP112 (centrosomal protein 112; 17q24.1) with delayed recall as well as SMOC2 (SPARC related modular calcium binding 2; 6p27) with immediate recall in a memory performance test. On the X chromosome, which is often excluded in other GWAS, we identified a genome-wide significant signal near IL1RAPL1 (interleukin 1 receptor accessory protein like 1; Xp21.3). While polygenic score (PGS) analyses showed the expected strong associations with SNPs highlighted in relevant previous GWAS on hippocampal volume and cognitive function, they did not show noteworthy associations with recent AD risk GWAS findings. In summary, our study highlights the power of using quantitative endophenotypes as outcome traits in AD-related GWAS analyses and nominates several new loci not previously implicated in cognitive decline. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8979334/ /pubmed/35386118 http://dx.doi.org/10.3389/fnagi.2022.840651 Text en Copyright © 2022 Homann, Osburg, Ohlei, Dobricic, Deecke, Bos, Vandenberghe, Gabel, Scheltens, Teunissen, Engelborghs, Frisoni, Blin, Richardson, Bordet, Lleó, Alcolea, Popp, Clark, Peyratout, Martinez-Lage, Tainta, Dobson, Legido-Quigley, Sleegers, Van Broeckhoven, Wittig, Franke, Lill, Blennow, Zetterberg, Lovestone, Streffer, ten Kate, Vos, Barkhof, Visser and Bertram. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Homann, Jan
Osburg, Tim
Ohlei, Olena
Dobricic, Valerija
Deecke, Laura
Bos, Isabelle
Vandenberghe, Rik
Gabel, Silvy
Scheltens, Philip
Teunissen, Charlotte E.
Engelborghs, Sebastiaan
Frisoni, Giovanni
Blin, Olivier
Richardson, Jill C.
Bordet, Regis
Lleó, Alberto
Alcolea, Daniel
Popp, Julius
Clark, Christopher
Peyratout, Gwendoline
Martinez-Lage, Pablo
Tainta, Mikel
Dobson, Richard J. B.
Legido-Quigley, Cristina
Sleegers, Kristel
Van Broeckhoven, Christine
Wittig, Michael
Franke, Andre
Lill, Christina M.
Blennow, Kaj
Zetterberg, Henrik
Lovestone, Simon
Streffer, Johannes
ten Kate, Mara
Vos, Stephanie J. B.
Barkhof, Frederik
Visser, Pieter Jelle
Bertram, Lars
Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
title Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
title_full Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
title_fullStr Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
title_full_unstemmed Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
title_short Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset
title_sort genome-wide association study of alzheimer’s disease brain imaging biomarkers and neuropsychological phenotypes in the european medical information framework for alzheimer’s disease multimodal biomarker discovery dataset
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979334/
https://www.ncbi.nlm.nih.gov/pubmed/35386118
http://dx.doi.org/10.3389/fnagi.2022.840651
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