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Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists

TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated in vitro and in vivo. The most potent compoun...

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Detalles Bibliográficos
Autores principales:	Zhao, Shizhen, Wang, Le, Wang, Jie, Wang, Chenwei, Zheng, Shaowei, Fu, Yajie, Li, Yunfu, Chen, Wei-Dong, Hou, Ruifang, Yang, Dongbin, Wang, Yan-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979340/ https://www.ncbi.nlm.nih.gov/pubmed/35425398 http://dx.doi.org/10.1039/d1ra08867j

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