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SuperDendrix algorithm integrates genetic dependencies and genomic alterations across pathways and cancer types

Recent genome-wide CRISPR-Cas9 loss-of-function screens have identified genetic dependencies across many cancer cell lines. Associations between these dependencies and genomic alterations in the same cell lines reveal phenomena such as oncogene addiction and synthetic lethality. However, comprehensi...

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Detalles Bibliográficos
Autores principales:	Park, Tae Yoon, Leiserson, Mark D.M., Klau, Gunnar W., Raphael, Benjamin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979493/ https://www.ncbi.nlm.nih.gov/pubmed/35382456 http://dx.doi.org/10.1016/j.xgen.2022.100099

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