Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease

In this work, we designed, synthesised and biologically investigated a novel series of 14 N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydrox...

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Detalles Bibliográficos
Autores principales: Przybyłowska, Maja, Dzierzbicka, Krystyna, Kowalski, Szymon, Demkowicz, Sebastian, Daśko, Mateusz, Inkielewicz-Stepniak, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979514/
https://www.ncbi.nlm.nih.gov/pubmed/35361039
http://dx.doi.org/10.1080/14756366.2022.2045591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979514/
https://www.ncbi.nlm.nih.gov/pubmed/35361039
http://dx.doi.org/10.1080/14756366.2022.2045591

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