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Loop extrusion promotes an alternate pathway for isotype switching

Class-switch recombination (CSR) involves replacement of the Cμ constant region with another downstream C(H) region. CSR is initiated by activation-induced cytidine deaminase (AID)-mediated DNA breaks that are targeted to transcriptionally active switch (S) regions. S region promoters (Prs) direct s...

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Detalles Bibliográficos
Autores principales:	Shen, Hong Ming, Wuerffel, Robert, Cantillo, Jose F., Priyadarshi, Saurabh, Lei, Xue, Liang, Jie, Wu, Yee Ling, Kenter, Amy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979556/ https://www.ncbi.nlm.nih.gov/pubmed/34818547 http://dx.doi.org/10.1016/j.celrep.2021.110059

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