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The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
OBJECTIVE: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. METHODS: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Pneumologia e Tisiologia
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979663/ https://www.ncbi.nlm.nih.gov/pubmed/34495173 http://dx.doi.org/10.36416/1806-3756/e20210018 |
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author | de Navarro, Pedro Daibert Haddad, João Paulo Amaral Rabelo, Juliana Veiga Costa Silva, Claudia Hermínia de Lima e de Almeida, Isabela Neves Carvalho, Wânia da Silva de Miranda, Silvana Spíndola |
author_facet | de Navarro, Pedro Daibert Haddad, João Paulo Amaral Rabelo, Juliana Veiga Costa Silva, Claudia Hermínia de Lima e de Almeida, Isabela Neves Carvalho, Wânia da Silva de Miranda, Silvana Spíndola |
author_sort | de Navarro, Pedro Daibert |
collection | PubMed |
description | OBJECTIVE: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. METHODS: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of 2016 and April of 2017. Cluster areas for tuberculosis were identified, and the units and their respective patients were divided into intervention (use of SRTB) and nonintervention groups. RESULTS: The total sample comprised 432 participants, 223 and 209 of whom being allocated to the nonintervention and intervention groups, respectively. The risk of treatment abandonment in the nonintervention group was significantly higher than was that in the intervention group (OR = 15.010; p < 0.001), regardless of the number of risk factors identified. Kaplan-Meier curves showed a hazard ratio of 0.0753 (p < 0.001). CONCLUSIONS: The SRTB instrument was effective in reducing abandonment of tuberculosis treatment, regardless of the number of risk factors for that. This instrument is rapid and easy to use, and can be adapted to different realities. Its application showed characteristics predisposing to a non-adherence to the treatment and established bases to mitigate its impact. |
format | Online Article Text |
id | pubmed-8979663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-89796632022-04-08 The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment de Navarro, Pedro Daibert Haddad, João Paulo Amaral Rabelo, Juliana Veiga Costa Silva, Claudia Hermínia de Lima e de Almeida, Isabela Neves Carvalho, Wânia da Silva de Miranda, Silvana Spíndola J Bras Pneumol Original Article OBJECTIVE: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. METHODS: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of 2016 and April of 2017. Cluster areas for tuberculosis were identified, and the units and their respective patients were divided into intervention (use of SRTB) and nonintervention groups. RESULTS: The total sample comprised 432 participants, 223 and 209 of whom being allocated to the nonintervention and intervention groups, respectively. The risk of treatment abandonment in the nonintervention group was significantly higher than was that in the intervention group (OR = 15.010; p < 0.001), regardless of the number of risk factors identified. Kaplan-Meier curves showed a hazard ratio of 0.0753 (p < 0.001). CONCLUSIONS: The SRTB instrument was effective in reducing abandonment of tuberculosis treatment, regardless of the number of risk factors for that. This instrument is rapid and easy to use, and can be adapted to different realities. Its application showed characteristics predisposing to a non-adherence to the treatment and established bases to mitigate its impact. Sociedade Brasileira de Pneumologia e Tisiologia 2021 /pmc/articles/PMC8979663/ /pubmed/34495173 http://dx.doi.org/10.36416/1806-3756/e20210018 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Original Article de Navarro, Pedro Daibert Haddad, João Paulo Amaral Rabelo, Juliana Veiga Costa Silva, Claudia Hermínia de Lima e de Almeida, Isabela Neves Carvalho, Wânia da Silva de Miranda, Silvana Spíndola The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
title | The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
title_full | The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
title_fullStr | The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
title_full_unstemmed | The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
title_short | The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
title_sort | impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979663/ https://www.ncbi.nlm.nih.gov/pubmed/34495173 http://dx.doi.org/10.36416/1806-3756/e20210018 |
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