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The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment

OBJECTIVE: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. METHODS: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis...

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Autores principales: de Navarro, Pedro Daibert, Haddad, João Paulo Amaral, Rabelo, Juliana Veiga Costa, Silva, Claudia Hermínia de Lima e, de Almeida, Isabela Neves, Carvalho, Wânia da Silva, de Miranda, Silvana Spíndola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979663/
https://www.ncbi.nlm.nih.gov/pubmed/34495173
http://dx.doi.org/10.36416/1806-3756/e20210018
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author de Navarro, Pedro Daibert
Haddad, João Paulo Amaral
Rabelo, Juliana Veiga Costa
Silva, Claudia Hermínia de Lima e
de Almeida, Isabela Neves
Carvalho, Wânia da Silva
de Miranda, Silvana Spíndola
author_facet de Navarro, Pedro Daibert
Haddad, João Paulo Amaral
Rabelo, Juliana Veiga Costa
Silva, Claudia Hermínia de Lima e
de Almeida, Isabela Neves
Carvalho, Wânia da Silva
de Miranda, Silvana Spíndola
author_sort de Navarro, Pedro Daibert
collection PubMed
description OBJECTIVE: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. METHODS: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of 2016 and April of 2017. Cluster areas for tuberculosis were identified, and the units and their respective patients were divided into intervention (use of SRTB) and nonintervention groups. RESULTS: The total sample comprised 432 participants, 223 and 209 of whom being allocated to the nonintervention and intervention groups, respectively. The risk of treatment abandonment in the nonintervention group was significantly higher than was that in the intervention group (OR = 15.010; p < 0.001), regardless of the number of risk factors identified. Kaplan-Meier curves showed a hazard ratio of 0.0753 (p < 0.001). CONCLUSIONS: The SRTB instrument was effective in reducing abandonment of tuberculosis treatment, regardless of the number of risk factors for that. This instrument is rapid and easy to use, and can be adapted to different realities. Its application showed characteristics predisposing to a non-adherence to the treatment and established bases to mitigate its impact.
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spelling pubmed-89796632022-04-08 The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment de Navarro, Pedro Daibert Haddad, João Paulo Amaral Rabelo, Juliana Veiga Costa Silva, Claudia Hermínia de Lima e de Almeida, Isabela Neves Carvalho, Wânia da Silva de Miranda, Silvana Spíndola J Bras Pneumol Original Article OBJECTIVE: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. METHODS: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of 2016 and April of 2017. Cluster areas for tuberculosis were identified, and the units and their respective patients were divided into intervention (use of SRTB) and nonintervention groups. RESULTS: The total sample comprised 432 participants, 223 and 209 of whom being allocated to the nonintervention and intervention groups, respectively. The risk of treatment abandonment in the nonintervention group was significantly higher than was that in the intervention group (OR = 15.010; p < 0.001), regardless of the number of risk factors identified. Kaplan-Meier curves showed a hazard ratio of 0.0753 (p < 0.001). CONCLUSIONS: The SRTB instrument was effective in reducing abandonment of tuberculosis treatment, regardless of the number of risk factors for that. This instrument is rapid and easy to use, and can be adapted to different realities. Its application showed characteristics predisposing to a non-adherence to the treatment and established bases to mitigate its impact. Sociedade Brasileira de Pneumologia e Tisiologia 2021 /pmc/articles/PMC8979663/ /pubmed/34495173 http://dx.doi.org/10.36416/1806-3756/e20210018 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
de Navarro, Pedro Daibert
Haddad, João Paulo Amaral
Rabelo, Juliana Veiga Costa
Silva, Claudia Hermínia de Lima e
de Almeida, Isabela Neves
Carvalho, Wânia da Silva
de Miranda, Silvana Spíndola
The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
title The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
title_full The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
title_fullStr The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
title_full_unstemmed The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
title_short The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
title_sort impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979663/
https://www.ncbi.nlm.nih.gov/pubmed/34495173
http://dx.doi.org/10.36416/1806-3756/e20210018
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