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Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy
OBJECTIVE: To investigate the effect of levothyroxine sodium tablets (L-T4) on pregnancy outcome and offspring development quotient in patients with subclinical hypothyroidism (SCH) during pregnancy. Material and Methods. Pregnant women with gestational age less than 12 weeks who underwent the first...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979691/ https://www.ncbi.nlm.nih.gov/pubmed/35388329 http://dx.doi.org/10.1155/2022/9001881 |
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author | Qian, Xiaoling Sun, Yunying Xu, Xiaohua |
author_facet | Qian, Xiaoling Sun, Yunying Xu, Xiaohua |
author_sort | Qian, Xiaoling |
collection | PubMed |
description | OBJECTIVE: To investigate the effect of levothyroxine sodium tablets (L-T4) on pregnancy outcome and offspring development quotient in patients with subclinical hypothyroidism (SCH) during pregnancy. Material and Methods. Pregnant women with gestational age less than 12 weeks who underwent the first prenatal examination in our hospital from January 2019 to December 2019 were prospectively selected as subjects. According to the level of thyroid hormone in pregnant women, they were divided into the treatment group (n = 63) and received L-T4 treatment, untreated group (n = 64), and control group (n = 54). Three groups of pregnancy outcomes, children's physical development, and the development of offspring were compared at when one full year of life. RESULTS: After treatment, the contrast difference of the three groups about abortion and gestational diabetes mellitus (GDM) was statistically significant (P < 0.05). The abortion rate and gestational diabetes mellitus (GDM) in the untreated group were higher than those in the control group (P < 0.05). The contrast difference of the treatment group and control group about abortion and gestational diabetes mellitus (GDM) is not statistically significant (P > 0.05); The contrast difference of the three groups about a filial generation at birth and one-year-old body length is not statistically significant (P > 0.05). The contrast difference between the three groups of individual children who are one-year old having the individual action energy, material ability, speech ability, and human ability is statistically significant (P < 0.05). One-year-old developmental quotient (DQ) of the treatment group and control group was higher than that of the untreated group (P < 0.05); the Pearson correlation analysis showed that the treatment group TSH levels have no correlation between the offspring developmental quotient (DQ) level of one-year-old children (P > 0.05). CONCLUSION: Levothyroxine sodium tablets (L-T4) can not only improve the pregnancy outcome of patients with SCH during pregnancy but also play a positive role in improving the neurointellectual development of their offspring. |
format | Online Article Text |
id | pubmed-8979691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89796912022-04-05 Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy Qian, Xiaoling Sun, Yunying Xu, Xiaohua J Healthc Eng Research Article OBJECTIVE: To investigate the effect of levothyroxine sodium tablets (L-T4) on pregnancy outcome and offspring development quotient in patients with subclinical hypothyroidism (SCH) during pregnancy. Material and Methods. Pregnant women with gestational age less than 12 weeks who underwent the first prenatal examination in our hospital from January 2019 to December 2019 were prospectively selected as subjects. According to the level of thyroid hormone in pregnant women, they were divided into the treatment group (n = 63) and received L-T4 treatment, untreated group (n = 64), and control group (n = 54). Three groups of pregnancy outcomes, children's physical development, and the development of offspring were compared at when one full year of life. RESULTS: After treatment, the contrast difference of the three groups about abortion and gestational diabetes mellitus (GDM) was statistically significant (P < 0.05). The abortion rate and gestational diabetes mellitus (GDM) in the untreated group were higher than those in the control group (P < 0.05). The contrast difference of the treatment group and control group about abortion and gestational diabetes mellitus (GDM) is not statistically significant (P > 0.05); The contrast difference of the three groups about a filial generation at birth and one-year-old body length is not statistically significant (P > 0.05). The contrast difference between the three groups of individual children who are one-year old having the individual action energy, material ability, speech ability, and human ability is statistically significant (P < 0.05). One-year-old developmental quotient (DQ) of the treatment group and control group was higher than that of the untreated group (P < 0.05); the Pearson correlation analysis showed that the treatment group TSH levels have no correlation between the offspring developmental quotient (DQ) level of one-year-old children (P > 0.05). CONCLUSION: Levothyroxine sodium tablets (L-T4) can not only improve the pregnancy outcome of patients with SCH during pregnancy but also play a positive role in improving the neurointellectual development of their offspring. Hindawi 2022-03-28 /pmc/articles/PMC8979691/ /pubmed/35388329 http://dx.doi.org/10.1155/2022/9001881 Text en Copyright © 2022 Xiaoling Qian et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Qian, Xiaoling Sun, Yunying Xu, Xiaohua Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy |
title | Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy |
title_full | Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy |
title_fullStr | Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy |
title_full_unstemmed | Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy |
title_short | Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy |
title_sort | effect of levothyroxine sodium tablets on pregnancy outcome and offspring development quotient of sch during pregnancy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979691/ https://www.ncbi.nlm.nih.gov/pubmed/35388329 http://dx.doi.org/10.1155/2022/9001881 |
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