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DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry

Taq1A polymorphism is a DRD2 gene variant located in an exon of the ANKK1 gene and has an important role in the brain's dopaminergic functions. Some studies have indicated that A1 carriers have an increased risk of developing Parkinson's disease (PD) and show poorer clinical performance th...

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Autores principales: Ohira, Kenji, Yokota, Hajime, Hirano, Shigeki, Nishimura, Motoi, Mukai, Hiroki, Horikoshi, Takuro, Sawai, Setsu, Yamanaka, Yoshitaka, Yamamoto, Tatsuya, Kakeda, Shingo, Kuwabara, Satoshi, Tanaka, Tomoaki, Uno, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979712/
https://www.ncbi.nlm.nih.gov/pubmed/35386951
http://dx.doi.org/10.1155/2022/8649195
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author Ohira, Kenji
Yokota, Hajime
Hirano, Shigeki
Nishimura, Motoi
Mukai, Hiroki
Horikoshi, Takuro
Sawai, Setsu
Yamanaka, Yoshitaka
Yamamoto, Tatsuya
Kakeda, Shingo
Kuwabara, Satoshi
Tanaka, Tomoaki
Uno, Takashi
author_facet Ohira, Kenji
Yokota, Hajime
Hirano, Shigeki
Nishimura, Motoi
Mukai, Hiroki
Horikoshi, Takuro
Sawai, Setsu
Yamanaka, Yoshitaka
Yamamoto, Tatsuya
Kakeda, Shingo
Kuwabara, Satoshi
Tanaka, Tomoaki
Uno, Takashi
author_sort Ohira, Kenji
collection PubMed
description Taq1A polymorphism is a DRD2 gene variant located in an exon of the ANKK1 gene and has an important role in the brain's dopaminergic functions. Some studies have indicated that A1 carriers have an increased risk of developing Parkinson's disease (PD) and show poorer clinical performance than A2 homo carriers. Previous studies have suggested that A1 carriers had fewer dopamine D2 receptors in the caudate and increased cortical activity as a compensatory mechanism. However, there is little information about morphological changes associated with this polymorphism in patients with PD. The study's aim was to investigate the relationship between brain volume and Taq1A polymorphism in PD using voxel-based morphometry (VBM). Based on Taq1A polymorphism, 103 patients with PD were divided into two groups: A1 carriers (A1/A1 and A1/A2) and A2 homo carriers (A2/A2). The volume of the left prefrontal cortex (PFC) was significantly decreased in A2 homo carriers compared to A1 carriers. This finding supports the association between Taq1A polymorphism and brain volume in PD and may explain the compensation of cortical function in A1 carriers with PD.
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spelling pubmed-89797122022-04-05 DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry Ohira, Kenji Yokota, Hajime Hirano, Shigeki Nishimura, Motoi Mukai, Hiroki Horikoshi, Takuro Sawai, Setsu Yamanaka, Yoshitaka Yamamoto, Tatsuya Kakeda, Shingo Kuwabara, Satoshi Tanaka, Tomoaki Uno, Takashi Parkinsons Dis Research Article Taq1A polymorphism is a DRD2 gene variant located in an exon of the ANKK1 gene and has an important role in the brain's dopaminergic functions. Some studies have indicated that A1 carriers have an increased risk of developing Parkinson's disease (PD) and show poorer clinical performance than A2 homo carriers. Previous studies have suggested that A1 carriers had fewer dopamine D2 receptors in the caudate and increased cortical activity as a compensatory mechanism. However, there is little information about morphological changes associated with this polymorphism in patients with PD. The study's aim was to investigate the relationship between brain volume and Taq1A polymorphism in PD using voxel-based morphometry (VBM). Based on Taq1A polymorphism, 103 patients with PD were divided into two groups: A1 carriers (A1/A1 and A1/A2) and A2 homo carriers (A2/A2). The volume of the left prefrontal cortex (PFC) was significantly decreased in A2 homo carriers compared to A1 carriers. This finding supports the association between Taq1A polymorphism and brain volume in PD and may explain the compensation of cortical function in A1 carriers with PD. Hindawi 2022-03-28 /pmc/articles/PMC8979712/ /pubmed/35386951 http://dx.doi.org/10.1155/2022/8649195 Text en Copyright © 2022 Kenji Ohira et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ohira, Kenji
Yokota, Hajime
Hirano, Shigeki
Nishimura, Motoi
Mukai, Hiroki
Horikoshi, Takuro
Sawai, Setsu
Yamanaka, Yoshitaka
Yamamoto, Tatsuya
Kakeda, Shingo
Kuwabara, Satoshi
Tanaka, Tomoaki
Uno, Takashi
DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry
title DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry
title_full DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry
title_fullStr DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry
title_full_unstemmed DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry
title_short DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry
title_sort drd2 taq1a polymorphism-related brain volume changes in parkinson's disease: voxel-based morphometry
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979712/
https://www.ncbi.nlm.nih.gov/pubmed/35386951
http://dx.doi.org/10.1155/2022/8649195
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