Inhibitors of Bcl-2 and Bruton’s tyrosine kinase synergize to abrogate diffuse large B-cell lymphoma growth in vitro and in orthotopic xenotransplantation models

Numerous targeted therapies have been developed for diffuse large B-cell lymphoma, but the results of late-stage clinical trials were mostly disappointing and have led to very few new regulatory approvals. Here, we use single and combinatorial drug response profiling to show that the combined inhibi...

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Detalles Bibliográficos
Autores principales: Bertram, Katrin, Leary, Peter John, Boudesco, Christophe, Fullin, Jonas, Stirm, Kristin, Dalal, Vineet, Zenz, Thorsten, Tzankov, Alexandar, Müller, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979814/
https://www.ncbi.nlm.nih.gov/pubmed/34795418
http://dx.doi.org/10.1038/s41375-021-01470-4

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