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Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicated Grb2-associated binder 2 (GAB2) as FLT3-ITD effector. Utilizing a Flt3-ITD knock-in, D...

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Detalles Bibliográficos
Autores principales:	Spohr, Corinna, Poggio, Teresa, Andrieux, Geoffroy, Schönberger, Katharina, Cabezas-Wallscheid, Nina, Boerries, Melanie, Halbach, Sebastian, Illert, Anna L., Brummer, Tilman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979819/ https://www.ncbi.nlm.nih.gov/pubmed/34903841 http://dx.doi.org/10.1038/s41375-021-01490-0

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