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Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?

OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio–video polysomnography (vP...

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Autores principales: Smardz, Joanna, Martynowicz, Helena, Wojakowska, Anna, Wezgowiec, Joanna, Olchowy, Cyprian, Danel, Dariusz, Mazur, Grzegorz, Wieckiewicz, Mieszko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979889/
https://www.ncbi.nlm.nih.gov/pubmed/34882257
http://dx.doi.org/10.1007/s00784-021-04329-1
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author Smardz, Joanna
Martynowicz, Helena
Wojakowska, Anna
Wezgowiec, Joanna
Olchowy, Cyprian
Danel, Dariusz
Mazur, Grzegorz
Wieckiewicz, Mieszko
author_facet Smardz, Joanna
Martynowicz, Helena
Wojakowska, Anna
Wezgowiec, Joanna
Olchowy, Cyprian
Danel, Dariusz
Mazur, Grzegorz
Wieckiewicz, Mieszko
author_sort Smardz, Joanna
collection PubMed
description OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio–video polysomnography (vPSG) and compare them with that of individuals not presenting with SB. MATERIALS AND METHODS: The study included adult patients hospitalized in the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at the Wroclaw Medical University. The participants underwent a single-night vPSG for the evaluation of the SB parameters. Peripheral blood samples were also collected from them for estimating the serum levels of TPH1 and DDC. RESULTS: A total of 105 patients (80 women and 25 men) were included in the study. All the patients were Caucasians and aged 18–63 years (mean age: 33.43 ± 10.8 years). Seventy-five patients (71.43%) presented with SB, of which 50 (47.62%) had severe SB, while the remaining 30 patients (28.57%) did not. No statistically significant differences in TPH1 and DDC levels were observed between the individuals with SB and without SB. A significant negative correlation was found between tonic SB episodes and DDC levels (p = 0.0012). Other correlations between the SB parameters and the levels of the studied enzymes were statistically insignificant (p > 0.05 for all comparisons). CONCLUSIONS: The levels of the enzymes that are crucial for serotonin synthesis (TPH1 and DDC) did not seem to influence SB. CLINICAL RELEVANCE: This study provides important insights for further research on the relationship between the serotonin pathway and SB, which should take into account not only the process of serotonin synthesis but also the effect of serotonin-dependent neurotransmission on SB.
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spelling pubmed-89798892022-04-22 Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway? Smardz, Joanna Martynowicz, Helena Wojakowska, Anna Wezgowiec, Joanna Olchowy, Cyprian Danel, Dariusz Mazur, Grzegorz Wieckiewicz, Mieszko Clin Oral Investig Original Article OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio–video polysomnography (vPSG) and compare them with that of individuals not presenting with SB. MATERIALS AND METHODS: The study included adult patients hospitalized in the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at the Wroclaw Medical University. The participants underwent a single-night vPSG for the evaluation of the SB parameters. Peripheral blood samples were also collected from them for estimating the serum levels of TPH1 and DDC. RESULTS: A total of 105 patients (80 women and 25 men) were included in the study. All the patients were Caucasians and aged 18–63 years (mean age: 33.43 ± 10.8 years). Seventy-five patients (71.43%) presented with SB, of which 50 (47.62%) had severe SB, while the remaining 30 patients (28.57%) did not. No statistically significant differences in TPH1 and DDC levels were observed between the individuals with SB and without SB. A significant negative correlation was found between tonic SB episodes and DDC levels (p = 0.0012). Other correlations between the SB parameters and the levels of the studied enzymes were statistically insignificant (p > 0.05 for all comparisons). CONCLUSIONS: The levels of the enzymes that are crucial for serotonin synthesis (TPH1 and DDC) did not seem to influence SB. CLINICAL RELEVANCE: This study provides important insights for further research on the relationship between the serotonin pathway and SB, which should take into account not only the process of serotonin synthesis but also the effect of serotonin-dependent neurotransmission on SB. Springer Berlin Heidelberg 2021-12-09 2022 /pmc/articles/PMC8979889/ /pubmed/34882257 http://dx.doi.org/10.1007/s00784-021-04329-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Smardz, Joanna
Martynowicz, Helena
Wojakowska, Anna
Wezgowiec, Joanna
Olchowy, Cyprian
Danel, Dariusz
Mazur, Grzegorz
Wieckiewicz, Mieszko
Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
title Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
title_full Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
title_fullStr Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
title_full_unstemmed Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
title_short Is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
title_sort is sleep bruxism related to the levels of enzymes involved in the serotonin synthesis pathway?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979889/
https://www.ncbi.nlm.nih.gov/pubmed/34882257
http://dx.doi.org/10.1007/s00784-021-04329-1
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