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Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review
Gastric intestinal metaplasia (IM) is a precancerous lesion that increases the risk of subsequent gastric cancer (GC) development. Therefore, the mechanism of IM has been the focus of basic and clinical research. Helicobacter pylori (H. pylori) infection has been recognized as the main pathogenesis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979943/ https://www.ncbi.nlm.nih.gov/pubmed/35379788 http://dx.doi.org/10.1038/s41420-022-00962-1 |
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author | He, Qijin Liu, Limin Wei, Jingge Jiang, Jiaying Rong, Zheng Chen, Xin Zhao, Jingwen Jiang, Kui |
author_facet | He, Qijin Liu, Limin Wei, Jingge Jiang, Jiaying Rong, Zheng Chen, Xin Zhao, Jingwen Jiang, Kui |
author_sort | He, Qijin |
collection | PubMed |
description | Gastric intestinal metaplasia (IM) is a precancerous lesion that increases the risk of subsequent gastric cancer (GC) development. Therefore, the mechanism of IM has been the focus of basic and clinical research. Helicobacter pylori (H. pylori) infection has been recognized as the main pathogenesis of gastric IM. However, more and more studies have shown that chronic inflammation of gastric mucosa caused by bile reflux is the key pathogenic factor of gastric IM. Bile reflux activates the expression of IM biomarkers via the bile acid receptor. In addition, microRNAs, exosomes, and epigenetics are also involved in the occurrence and development of bile acid-induced gastric IM. Currently, the relevant research is still very few. The molecular mechanism of the phenotypic transformation of gastrointestinal epithelial cells induced by bile acids has not been fully understood. This article mainly reviews the physiology and pathology of bile acid, mechanism of gastric IM induced by bile acid, bile acid receptors, and so on, in order to provide reference for further research. |
format | Online Article Text |
id | pubmed-8979943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89799432022-04-20 Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review He, Qijin Liu, Limin Wei, Jingge Jiang, Jiaying Rong, Zheng Chen, Xin Zhao, Jingwen Jiang, Kui Cell Death Discov Review Article Gastric intestinal metaplasia (IM) is a precancerous lesion that increases the risk of subsequent gastric cancer (GC) development. Therefore, the mechanism of IM has been the focus of basic and clinical research. Helicobacter pylori (H. pylori) infection has been recognized as the main pathogenesis of gastric IM. However, more and more studies have shown that chronic inflammation of gastric mucosa caused by bile reflux is the key pathogenic factor of gastric IM. Bile reflux activates the expression of IM biomarkers via the bile acid receptor. In addition, microRNAs, exosomes, and epigenetics are also involved in the occurrence and development of bile acid-induced gastric IM. Currently, the relevant research is still very few. The molecular mechanism of the phenotypic transformation of gastrointestinal epithelial cells induced by bile acids has not been fully understood. This article mainly reviews the physiology and pathology of bile acid, mechanism of gastric IM induced by bile acid, bile acid receptors, and so on, in order to provide reference for further research. Nature Publishing Group UK 2022-04-04 /pmc/articles/PMC8979943/ /pubmed/35379788 http://dx.doi.org/10.1038/s41420-022-00962-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article He, Qijin Liu, Limin Wei, Jingge Jiang, Jiaying Rong, Zheng Chen, Xin Zhao, Jingwen Jiang, Kui Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
title | Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
title_full | Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
title_fullStr | Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
title_full_unstemmed | Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
title_short | Roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
title_sort | roles and action mechanisms of bile acid-induced gastric intestinal metaplasia: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979943/ https://www.ncbi.nlm.nih.gov/pubmed/35379788 http://dx.doi.org/10.1038/s41420-022-00962-1 |
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