A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes

Translation of the hexanucleotide G4C2 expansion associated with C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) produces five different dipeptide repeat protein (DPR) species that can confer toxicity. There is yet much to learn about the contribution of a single DPR to d...

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Detalles Bibliográficos
Autores principales: Verdone, Brandie Morris, Cicardi, Maria Elena, Wen, Xinmei, Sriramoji, Sindhu, Russell, Katelyn, Markandaiah, Shashirekha S., Jensen, Brigid K., Krishnamurthy, Karthik, Haeusler, Aaron R., Pasinelli, Piera, Trotti, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979946/
https://www.ncbi.nlm.nih.gov/pubmed/35379876
http://dx.doi.org/10.1038/s41598-022-09593-z

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