Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance

The anti-apoptotic protein HAX-1 has been proposed to modulate mitochondrial membrane potential, calcium signaling and actin remodeling. HAX-1 mutation or deficiency results in severe congenital neutropenia (SCN), loss of lymphocytes and neurological impairments by largely unknown mechanisms. Here,...

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Detalles Bibliográficos
Autores principales: Dong, Qincai, Li, Dapei, Zhao, Huailong, Zhang, Xun, Liu, Yue, Hu, Yong, Yao, Yi, Zhu, Lin, Wang, Guang-Fei, Liu, Hainan, Gao, Ting, Niu, Xiayang, Zheng, Tong, Song, Caiwei, Wang, Di, Bai, Yu, Jin, Jing, Liu, Zijing, Jin, Yanwen, Li, Ping, Cao, Cheng, Liu, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979985/
https://www.ncbi.nlm.nih.gov/pubmed/35379774
http://dx.doi.org/10.1038/s41419-022-04748-2

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