Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis

Chronic exposure to bile acid in the liver due to impaired bile flow induces cholestatic liver disease, resulting in hepatotoxicity and liver fibrosis. Sestrin2, a highly conserved, stress-inducible protein, has been implicated in cellular responses to multiple stress conditions and the maintenance...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Daewon, Kim, Haeil, Kim, Soojin, Le, Qui Anh, Han, Seung Yun, Bae, Jeongyun, Shin, Hye Won, Kang, Hyun-Goo, Han, Kyung Ho, Shin, Jongdae, Park, Hwan-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980001/
https://www.ncbi.nlm.nih.gov/pubmed/35260799
http://dx.doi.org/10.1038/s12276-022-00737-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980001/
https://www.ncbi.nlm.nih.gov/pubmed/35260799
http://dx.doi.org/10.1038/s12276-022-00737-9

Ejemplares similares