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Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis
Chronic exposure to bile acid in the liver due to impaired bile flow induces cholestatic liver disease, resulting in hepatotoxicity and liver fibrosis. Sestrin2, a highly conserved, stress-inducible protein, has been implicated in cellular responses to multiple stress conditions and the maintenance...
Autores principales: | Han, Daewon, Kim, Haeil, Kim, Soojin, Le, Qui Anh, Han, Seung Yun, Bae, Jeongyun, Shin, Hye Won, Kang, Hyun-Goo, Han, Kyung Ho, Shin, Jongdae, Park, Hwan-Woo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980001/ https://www.ncbi.nlm.nih.gov/pubmed/35260799 http://dx.doi.org/10.1038/s12276-022-00737-9 |
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