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The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes

The ER stress and Unfolded Protein Response (UPR) component inositol-requiring enzyme 1α (IRE1α) has been linked to inflammation and lipid mediator production. Here we report that the potent IRE1α inhibitor, KIRA6, blocks leukotriene biosynthesis in human phagocytes activated with lipopolysaccharide...

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Detalles Bibliográficos
Autores principales:	Tang, Xiao, Teder, Tarvi, Samuelsson, Bengt, Haeggström, Jesper Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980214/ https://www.ncbi.nlm.nih.gov/pubmed/35392553 http://dx.doi.org/10.3389/fphar.2022.806240

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