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Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder

Recent studies suggest that individual difference in intra-individual variability (IIV) of reaction times is an important indicator of attentional executive control. However, there are few existing studies on the executive control of high trait-anxious individuals assessed by using reaction time var...

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Autores principales: Yu, Yongju, Xu, Haiyan, Xu, Yuanyuan, Lu, Fang, Li, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980260/
https://www.ncbi.nlm.nih.gov/pubmed/35392390
http://dx.doi.org/10.3389/fpsyt.2022.532778
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author Yu, Yongju
Xu, Haiyan
Xu, Yuanyuan
Lu, Fang
Li, Min
author_facet Yu, Yongju
Xu, Haiyan
Xu, Yuanyuan
Lu, Fang
Li, Min
author_sort Yu, Yongju
collection PubMed
description Recent studies suggest that individual difference in intra-individual variability (IIV) of reaction times is an important indicator of attentional executive control. However, there are few existing studies on the executive control of high trait-anxious individuals assessed by using reaction time variability. This study assessed whether executive functions are impaired among clinical and non-clinical trait-anxious individuals indicated by IIV. The cross-reliability and discriminative power of three IIV parameters (raw intra-individual standard deviation, SD; reaction time coefficient of variation, RTCV; and mean absolute deviation, MAD) were compared. Twenty-five non-clinical individuals with low trait anxiety (LTA), 31 non-clinical individuals with high trait anxiety (HTA), and 19 clinical patients diagnosed with generalized anxiety disorder (GAD) finished self-reported measures, an emotional spatial-cuing task, and a non-emotional arrow flanker task. In the emotional task, GAD patients had significantly slower response speed, lower accuracy, and greater IIV parameters than the LTA and HTA groups. In the non-emotional task, the GAD group exhibited poorer processing efficiency, greater SD and RTCV, and intact performance effectiveness. RTCV is suggested to be a better marker of executive dysfunction than SD and MAD due to its good discriminative power and reliability as well as less affected by reaction times.
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spelling pubmed-89802602022-04-06 Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder Yu, Yongju Xu, Haiyan Xu, Yuanyuan Lu, Fang Li, Min Front Psychiatry Psychiatry Recent studies suggest that individual difference in intra-individual variability (IIV) of reaction times is an important indicator of attentional executive control. However, there are few existing studies on the executive control of high trait-anxious individuals assessed by using reaction time variability. This study assessed whether executive functions are impaired among clinical and non-clinical trait-anxious individuals indicated by IIV. The cross-reliability and discriminative power of three IIV parameters (raw intra-individual standard deviation, SD; reaction time coefficient of variation, RTCV; and mean absolute deviation, MAD) were compared. Twenty-five non-clinical individuals with low trait anxiety (LTA), 31 non-clinical individuals with high trait anxiety (HTA), and 19 clinical patients diagnosed with generalized anxiety disorder (GAD) finished self-reported measures, an emotional spatial-cuing task, and a non-emotional arrow flanker task. In the emotional task, GAD patients had significantly slower response speed, lower accuracy, and greater IIV parameters than the LTA and HTA groups. In the non-emotional task, the GAD group exhibited poorer processing efficiency, greater SD and RTCV, and intact performance effectiveness. RTCV is suggested to be a better marker of executive dysfunction than SD and MAD due to its good discriminative power and reliability as well as less affected by reaction times. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8980260/ /pubmed/35392390 http://dx.doi.org/10.3389/fpsyt.2022.532778 Text en Copyright © 2022 Yu, Xu, Xu, Lu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Yu, Yongju
Xu, Haiyan
Xu, Yuanyuan
Lu, Fang
Li, Min
Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder
title Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder
title_full Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder
title_fullStr Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder
title_full_unstemmed Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder
title_short Increased Intra-Individual Variability as a Marker of Executive Dysfunction in Generalized Anxiety Disorder
title_sort increased intra-individual variability as a marker of executive dysfunction in generalized anxiety disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980260/
https://www.ncbi.nlm.nih.gov/pubmed/35392390
http://dx.doi.org/10.3389/fpsyt.2022.532778
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