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The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles

OBJECTIVE: The time interval between transcranial magnetic stimulation (TMS) pulses affects evoked muscle responses when the targeted muscle is resting. This necessitates using sufficiently long inter-pulse intervals (IPIs). However, there is some evidence that the IPI has no effect on the responses...

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Autores principales: Matilainen, Noora, Soldati, Marco, Laakso, Ilkka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980278/
https://www.ncbi.nlm.nih.gov/pubmed/35392119
http://dx.doi.org/10.3389/fnhum.2022.845476
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author Matilainen, Noora
Soldati, Marco
Laakso, Ilkka
author_facet Matilainen, Noora
Soldati, Marco
Laakso, Ilkka
author_sort Matilainen, Noora
collection PubMed
description OBJECTIVE: The time interval between transcranial magnetic stimulation (TMS) pulses affects evoked muscle responses when the targeted muscle is resting. This necessitates using sufficiently long inter-pulse intervals (IPIs). However, there is some evidence that the IPI has no effect on the responses evoked in active muscles. Thus, we tested whether voluntary contraction could remove the effect of the IPI on TMS motor evoked potentials (MEPs). METHODS: In our study, we delivered sets of 30 TMS pulses with three different IPIs (2, 5, and 10 s) to the left primary motor cortex. These measurements were performed with the resting and active right hand first dorsal interosseous muscle in healthy participants (N = 9 and N = 10). MEP amplitudes were recorded through electromyography. RESULTS: We found that the IPI had no significant effect on the MEP amplitudes in the active muscle (p = 0.36), whereas in the resting muscle, the IPI significantly affected the MEP amplitudes (p < 0.001), decreasing the MEP amplitude of the 2 s IPI. CONCLUSIONS: These results show that active muscle contraction removes the effect of the IPI on the MEP amplitude. Therefore, using active muscles in TMS motor mapping enables faster delivery of TMS pulses, reducing measurement time in novel TMS motor mapping studies.
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spelling pubmed-89802782022-04-06 The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles Matilainen, Noora Soldati, Marco Laakso, Ilkka Front Hum Neurosci Human Neuroscience OBJECTIVE: The time interval between transcranial magnetic stimulation (TMS) pulses affects evoked muscle responses when the targeted muscle is resting. This necessitates using sufficiently long inter-pulse intervals (IPIs). However, there is some evidence that the IPI has no effect on the responses evoked in active muscles. Thus, we tested whether voluntary contraction could remove the effect of the IPI on TMS motor evoked potentials (MEPs). METHODS: In our study, we delivered sets of 30 TMS pulses with three different IPIs (2, 5, and 10 s) to the left primary motor cortex. These measurements were performed with the resting and active right hand first dorsal interosseous muscle in healthy participants (N = 9 and N = 10). MEP amplitudes were recorded through electromyography. RESULTS: We found that the IPI had no significant effect on the MEP amplitudes in the active muscle (p = 0.36), whereas in the resting muscle, the IPI significantly affected the MEP amplitudes (p < 0.001), decreasing the MEP amplitude of the 2 s IPI. CONCLUSIONS: These results show that active muscle contraction removes the effect of the IPI on the MEP amplitude. Therefore, using active muscles in TMS motor mapping enables faster delivery of TMS pulses, reducing measurement time in novel TMS motor mapping studies. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8980278/ /pubmed/35392119 http://dx.doi.org/10.3389/fnhum.2022.845476 Text en Copyright © 2022 Matilainen, Soldati and Laakso. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Matilainen, Noora
Soldati, Marco
Laakso, Ilkka
The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles
title The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles
title_full The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles
title_fullStr The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles
title_full_unstemmed The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles
title_short The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles
title_sort effect of inter-pulse interval on tms motor evoked potentials in active muscles
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980278/
https://www.ncbi.nlm.nih.gov/pubmed/35392119
http://dx.doi.org/10.3389/fnhum.2022.845476
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