Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME)...

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Autores principales: Tu, Bin, Gao, Yanrong, Sun, Feifei, Shi, Mingjie, Huang, Yongzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980325/
https://www.ncbi.nlm.nih.gov/pubmed/35392570
http://dx.doi.org/10.3389/fphar.2022.840440
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author Tu, Bin
Gao, Yanrong
Sun, Feifei
Shi, Mingjie
Huang, Yongzhuo
author_facet Tu, Bin
Gao, Yanrong
Sun, Feifei
Shi, Mingjie
Huang, Yongzhuo
author_sort Tu, Bin
collection PubMed
description The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses.
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spelling pubmed-89803252022-04-06 Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity Tu, Bin Gao, Yanrong Sun, Feifei Shi, Mingjie Huang, Yongzhuo Front Pharmacol Pharmacology The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8980325/ /pubmed/35392570 http://dx.doi.org/10.3389/fphar.2022.840440 Text en Copyright © 2022 Tu, Gao, Sun, Shi and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tu, Bin
Gao, Yanrong
Sun, Feifei
Shi, Mingjie
Huang, Yongzhuo
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
title Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
title_full Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
title_fullStr Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
title_full_unstemmed Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
title_short Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
title_sort lipid metabolism regulation based on nanotechnology for enhancement of tumor immunity
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980325/
https://www.ncbi.nlm.nih.gov/pubmed/35392570
http://dx.doi.org/10.3389/fphar.2022.840440
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AT sunfeifei lipidmetabolismregulationbasedonnanotechnologyforenhancementoftumorimmunity
AT shimingjie lipidmetabolismregulationbasedonnanotechnologyforenhancementoftumorimmunity
AT huangyongzhuo lipidmetabolismregulationbasedonnanotechnologyforenhancementoftumorimmunity

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