Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice

Glutathione peroxidase 4 (GPx4) is known for its unique function in the direct detoxification of lipid peroxides in the cell membrane and as a key regulator of ferroptosis, a form of lipid peroxidation–induced nonapoptotic cell death. However, the cytosolic isoform of GPx4 is considered to play a ma...

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Detalles Bibliográficos
Autores principales: Azuma, Kunihiro, Koumura, Tomoko, Iwamoto, Ryo, Matsuoka, Masaki, Terauchi, Ryo, Yasuda, Shu, Shiraya, Tomoyasu, Watanabe, Sumiko, Aihara, Makoto, Imai, Hirotaka, Ueta, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980337/
https://www.ncbi.nlm.nih.gov/pubmed/35288190
http://dx.doi.org/10.1016/j.jbc.2022.101824

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