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Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke

BACKGROUND: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. METHODS: Using a multicenter prospec...

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Autores principales: Kim, Jun Yup, Lee, Keon-Joo, Kang, Jihoon, Kim, Beom Joon, Han, Moon-Ku, Kang, Kyusik, Park, Jong-Moo, Park, Tai Hwan, Park, Hong-Kyun, Cho, Yong-Jin, Hong, Keun-Sik, Lee, Kyung Bok, Jang, Myung Suk, Lee, Ji Sung, Lee, Juneyoung, Bae, Hee-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980366/
https://www.ncbi.nlm.nih.gov/pubmed/35380025
http://dx.doi.org/10.3346/jkms.2022.37.e100
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author Kim, Jun Yup
Lee, Keon-Joo
Kang, Jihoon
Kim, Beom Joon
Han, Moon-Ku
Kang, Kyusik
Park, Jong-Moo
Park, Tai Hwan
Park, Hong-Kyun
Cho, Yong-Jin
Hong, Keun-Sik
Lee, Kyung Bok
Jang, Myung Suk
Lee, Ji Sung
Lee, Juneyoung
Bae, Hee-Joon
author_facet Kim, Jun Yup
Lee, Keon-Joo
Kang, Jihoon
Kim, Beom Joon
Han, Moon-Ku
Kang, Kyusik
Park, Jong-Moo
Park, Tai Hwan
Park, Hong-Kyun
Cho, Yong-Jin
Hong, Keun-Sik
Lee, Kyung Bok
Jang, Myung Suk
Lee, Ji Sung
Lee, Juneyoung
Bae, Hee-Joon
author_sort Kim, Jun Yup
collection PubMed
description BACKGROUND: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. METHODS: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year. RESULTS: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever-smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles. CONCLUSION: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.
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spelling pubmed-89803662022-04-13 Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke Kim, Jun Yup Lee, Keon-Joo Kang, Jihoon Kim, Beom Joon Han, Moon-Ku Kang, Kyusik Park, Jong-Moo Park, Tai Hwan Park, Hong-Kyun Cho, Yong-Jin Hong, Keun-Sik Lee, Kyung Bok Jang, Myung Suk Lee, Ji Sung Lee, Juneyoung Bae, Hee-Joon J Korean Med Sci Original Article BACKGROUND: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. METHODS: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year. RESULTS: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever-smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles. CONCLUSION: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year. The Korean Academy of Medical Sciences 2022-03-29 /pmc/articles/PMC8980366/ /pubmed/35380025 http://dx.doi.org/10.3346/jkms.2022.37.e100 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jun Yup
Lee, Keon-Joo
Kang, Jihoon
Kim, Beom Joon
Han, Moon-Ku
Kang, Kyusik
Park, Jong-Moo
Park, Tai Hwan
Park, Hong-Kyun
Cho, Yong-Jin
Hong, Keun-Sik
Lee, Kyung Bok
Jang, Myung Suk
Lee, Ji Sung
Lee, Juneyoung
Bae, Hee-Joon
Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
title Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
title_full Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
title_fullStr Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
title_full_unstemmed Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
title_short Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
title_sort fasting and non-fasting triglycerides in patients with acute ischemic stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980366/
https://www.ncbi.nlm.nih.gov/pubmed/35380025
http://dx.doi.org/10.3346/jkms.2022.37.e100
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