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Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality

BACKGROUND AND AIM: Milk produced from Awassi sheep is of high nutritive value; its production is relatively low in Awassi sheep, so the genetic improvement programs targeted milk production and its components are of high importance, especially when using genes that have an important signal to milk...

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Autores principales: Al-Amareen, Ahmad H., Jawasreh, Khaleel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980402/
https://www.ncbi.nlm.nih.gov/pubmed/35400971
http://dx.doi.org/10.14202/vetworld.2022.435-441
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author Al-Amareen, Ahmad H.
Jawasreh, Khaleel I.
author_facet Al-Amareen, Ahmad H.
Jawasreh, Khaleel I.
author_sort Al-Amareen, Ahmad H.
collection PubMed
description BACKGROUND AND AIM: Milk produced from Awassi sheep is of high nutritive value; its production is relatively low in Awassi sheep, so the genetic improvement programs targeted milk production and its components are of high importance, especially when using genes that have an important signal to milk traits. This study was aimed at assessing the influence of alpha S1 (CSN1S1) and beta-casein (CSN2) genes genotypes interaction on Awassi ewes milk productivity. MATERIALS AND METHODS: A total number of 391 milk yield and its composition records (taken through five consecutive years, 2007-2011) of 167 ewes were utilized for this study. DNA samples were extracted from the ewe’s blood samples, then the polymerase chain reaction products of alpha S1 (CSN1S1) and beta-casein (CSN2) genes were sequenced. The obtained sequences were analyzed; thereafter, the detected variants were tested for their possible association with milk traits. RESULTS: The CSN1S1 and CSN2 variants allelic frequencies were 0.85 and 0.15, and 0.95 and 0.05, respectively. Lactose and solid not fat (SNF) % were associated with TC CSN1S1 genotypes. No association was found among CSN1S1 polymorphic genotypes with milk production, lactose, and SNF % were associated with TC CSN1S1 genotypes. Ewes of CSN2 AC genotype showed higher milk production traits, while no association was found between milk composition traits and CNS2 genotypes. Nevertheless, CSN1S1*CSN2 interaction showed the highest SNF, fat percentages, and milk production. CONCLUSION: The substantial interaction effects between CSN1S1×CSN2 genes were significantly affected the amount of milk, fat, and SNF% produced. The detected variants should be included in the breeding programs of Awassi sheep that are designed for improving their milk quantity and quality.
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spelling pubmed-89804022022-04-08 Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality Al-Amareen, Ahmad H. Jawasreh, Khaleel I. Vet World Research Article BACKGROUND AND AIM: Milk produced from Awassi sheep is of high nutritive value; its production is relatively low in Awassi sheep, so the genetic improvement programs targeted milk production and its components are of high importance, especially when using genes that have an important signal to milk traits. This study was aimed at assessing the influence of alpha S1 (CSN1S1) and beta-casein (CSN2) genes genotypes interaction on Awassi ewes milk productivity. MATERIALS AND METHODS: A total number of 391 milk yield and its composition records (taken through five consecutive years, 2007-2011) of 167 ewes were utilized for this study. DNA samples were extracted from the ewe’s blood samples, then the polymerase chain reaction products of alpha S1 (CSN1S1) and beta-casein (CSN2) genes were sequenced. The obtained sequences were analyzed; thereafter, the detected variants were tested for their possible association with milk traits. RESULTS: The CSN1S1 and CSN2 variants allelic frequencies were 0.85 and 0.15, and 0.95 and 0.05, respectively. Lactose and solid not fat (SNF) % were associated with TC CSN1S1 genotypes. No association was found among CSN1S1 polymorphic genotypes with milk production, lactose, and SNF % were associated with TC CSN1S1 genotypes. Ewes of CSN2 AC genotype showed higher milk production traits, while no association was found between milk composition traits and CNS2 genotypes. Nevertheless, CSN1S1*CSN2 interaction showed the highest SNF, fat percentages, and milk production. CONCLUSION: The substantial interaction effects between CSN1S1×CSN2 genes were significantly affected the amount of milk, fat, and SNF% produced. The detected variants should be included in the breeding programs of Awassi sheep that are designed for improving their milk quantity and quality. Veterinary World 2022-02 2022-02-25 /pmc/articles/PMC8980402/ /pubmed/35400971 http://dx.doi.org/10.14202/vetworld.2022.435-441 Text en Copyright: © Al-Amareen and Jawasreh, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Al-Amareen, Ahmad H.
Jawasreh, Khaleel I.
Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality
title Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality
title_full Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality
title_fullStr Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality
title_full_unstemmed Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality
title_short Single and combined effects of CSN1S1 and CSN2-casein genes on Awassi sheep milk quantity and quality
title_sort single and combined effects of csn1s1 and csn2-casein genes on awassi sheep milk quantity and quality
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980402/
https://www.ncbi.nlm.nih.gov/pubmed/35400971
http://dx.doi.org/10.14202/vetworld.2022.435-441
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