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Osthole-Mediated Inhibition of Neurotoxicity Induced by Ropivacaine via Amplification of the Cyclic Adenosine Monophosphate Signaling Pathway

BACKGROUND: Ropivacaine is widely used for clinical anesthesia and postoperative analgesia. However, the neurotoxicity induced by ropivacaine in a concentration- and duration-dependent manner, and it is difficult to prevent neurotoxicity. Osthole inhibits phosphodiesterase-4 activity by binding to i...

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Detalles Bibliográficos
Autores principales: Wang, WeiBing, Zhou, Hui, Sun, LaiBao, Li, MeiNa, Gao, FengJiao, Sun, AiJiao, Zou, XueNong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980408/
https://www.ncbi.nlm.nih.gov/pubmed/35392264
http://dx.doi.org/10.1177/15593258221088092