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Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center

PURPOSE: Hepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis. METHODS: The clinical data from children with high-risk HB or HB tumor rupture...

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Autores principales: Zhang, Yu-Tong, Zhao, Yu-Fei, Yang, Dian-Fei, Chang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980550/
https://www.ncbi.nlm.nih.gov/pubmed/35391745
http://dx.doi.org/10.3389/fped.2022.799307
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author Zhang, Yu-Tong
Zhao, Yu-Fei
Yang, Dian-Fei
Chang, Jian
author_facet Zhang, Yu-Tong
Zhao, Yu-Fei
Yang, Dian-Fei
Chang, Jian
author_sort Zhang, Yu-Tong
collection PubMed
description PURPOSE: Hepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis. METHODS: The clinical data from children with high-risk HB or HB tumor rupture at our institution from October 2008 to 2017 were retrospectively reviewed and analyzed. RESULTS: Together, 34 children with high-risk HB or HB tumor rupture were retrospected, including 25 in the high-risk group and nine in tumor rupture group. The 3-year overall survival (OS) rate in tumor rupture group was significantly higher than that of the high-risk group (100 vs. 64%, p = 0.0427). In tumor rupture group, seven (77.8%) of nine patients had a hemoglobin level ≤ 8 g/L and 3 of them (33.3%) had ≤ 6 g/L at the time of diagnosis. Peritoneal perfusion with interleukin-2 was implemented for each patient. At the end of the treatment, seven (77.8%) of nine patients achieved complete response (CR). No patient died at the last follow-up. CONCLUSIONS: HB tumor rupture might not be predictive of poor prognosis with the risk of peritoneal dissemination/relapse, in which peritoneal perfusion with interleukin-2 could play a role.
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spelling pubmed-89805502022-04-06 Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center Zhang, Yu-Tong Zhao, Yu-Fei Yang, Dian-Fei Chang, Jian Front Pediatr Pediatrics PURPOSE: Hepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis. METHODS: The clinical data from children with high-risk HB or HB tumor rupture at our institution from October 2008 to 2017 were retrospectively reviewed and analyzed. RESULTS: Together, 34 children with high-risk HB or HB tumor rupture were retrospected, including 25 in the high-risk group and nine in tumor rupture group. The 3-year overall survival (OS) rate in tumor rupture group was significantly higher than that of the high-risk group (100 vs. 64%, p = 0.0427). In tumor rupture group, seven (77.8%) of nine patients had a hemoglobin level ≤ 8 g/L and 3 of them (33.3%) had ≤ 6 g/L at the time of diagnosis. Peritoneal perfusion with interleukin-2 was implemented for each patient. At the end of the treatment, seven (77.8%) of nine patients achieved complete response (CR). No patient died at the last follow-up. CONCLUSIONS: HB tumor rupture might not be predictive of poor prognosis with the risk of peritoneal dissemination/relapse, in which peritoneal perfusion with interleukin-2 could play a role. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8980550/ /pubmed/35391745 http://dx.doi.org/10.3389/fped.2022.799307 Text en Copyright © 2022 Zhang, Zhao, Yang and Chang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Zhang, Yu-Tong
Zhao, Yu-Fei
Yang, Dian-Fei
Chang, Jian
Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center
title Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center
title_full Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center
title_fullStr Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center
title_full_unstemmed Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center
title_short Retrospective Analysis of Pediatric Hepatoblastoma With Tumor Rupture: Experience From a Single Center
title_sort retrospective analysis of pediatric hepatoblastoma with tumor rupture: experience from a single center
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980550/
https://www.ncbi.nlm.nih.gov/pubmed/35391745
http://dx.doi.org/10.3389/fped.2022.799307
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