Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G

HIV-1 encodes accessory proteins that neutralize antiviral restriction factors to ensure its successful replication. One accessory protein, the HIV-1 viral infectivity factor (Vif), is known to promote ubiquitination and proteasomal degradation of the antiviral restriction factor apolipoprotein B mR...

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Detalles Bibliográficos
Autores principales: Raja, Rameez, Wang, Chenyao, Mishra, Ritu, Das, Arundhoti, Ali, Amjad, Banerjea, Akhil C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980627/
https://www.ncbi.nlm.nih.gov/pubmed/35259395
http://dx.doi.org/10.1016/j.jbc.2022.101805

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