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Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. While some pathologies are exacerbated by lymphati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980686/ https://www.ncbi.nlm.nih.gov/pubmed/35392370 http://dx.doi.org/10.3389/fphys.2022.846936 |
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author | Masood, Faisal Bhattaram, Rohan Rosenblatt, Mark I. Kazlauskas, Andrius Chang, Jin-Hong Azar, Dimitri T. |
author_facet | Masood, Faisal Bhattaram, Rohan Rosenblatt, Mark I. Kazlauskas, Andrius Chang, Jin-Hong Azar, Dimitri T. |
author_sort | Masood, Faisal |
collection | PubMed |
description | Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. While some pathologies are exacerbated by lymphatic vessel regression and dysfunction, induced lymphatic regression could be therapeutically beneficial in others. Despite its importance, our understanding of lymphatic vessel regression is far behind that of blood vessel regression. Herein, we review the current understanding of blood vessel regression to identify several hallmarks of this phenomenon that can be extended to further our understanding of lymphatic vessel regression. We also summarize current research on lymphatic vessel regression and an array of research tools and models that can be utilized to advance this field. Additionally, we discuss the roles of lymphatic vessel regression and dysfunction in select pathologies, highlighting how an improved understanding of lymphatic vessel regression may yield therapeutic insights for these disease states. |
format | Online Article Text |
id | pubmed-8980686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89806862022-04-06 Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression Masood, Faisal Bhattaram, Rohan Rosenblatt, Mark I. Kazlauskas, Andrius Chang, Jin-Hong Azar, Dimitri T. Front Physiol Physiology Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. While some pathologies are exacerbated by lymphatic vessel regression and dysfunction, induced lymphatic regression could be therapeutically beneficial in others. Despite its importance, our understanding of lymphatic vessel regression is far behind that of blood vessel regression. Herein, we review the current understanding of blood vessel regression to identify several hallmarks of this phenomenon that can be extended to further our understanding of lymphatic vessel regression. We also summarize current research on lymphatic vessel regression and an array of research tools and models that can be utilized to advance this field. Additionally, we discuss the roles of lymphatic vessel regression and dysfunction in select pathologies, highlighting how an improved understanding of lymphatic vessel regression may yield therapeutic insights for these disease states. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8980686/ /pubmed/35392370 http://dx.doi.org/10.3389/fphys.2022.846936 Text en Copyright © 2022 Masood, Bhattaram, Rosenblatt, Kazlauskas, Chang and Azar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Masood, Faisal Bhattaram, Rohan Rosenblatt, Mark I. Kazlauskas, Andrius Chang, Jin-Hong Azar, Dimitri T. Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression |
title | Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression |
title_full | Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression |
title_fullStr | Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression |
title_full_unstemmed | Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression |
title_short | Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression |
title_sort | lymphatic vessel regression and its therapeutic applications: learning from principles of blood vessel regression |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980686/ https://www.ncbi.nlm.nih.gov/pubmed/35392370 http://dx.doi.org/10.3389/fphys.2022.846936 |
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