Cargando…

Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression

Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. While some pathologies are exacerbated by lymphati...

Descripción completa

Detalles Bibliográficos
Autores principales: Masood, Faisal, Bhattaram, Rohan, Rosenblatt, Mark I., Kazlauskas, Andrius, Chang, Jin-Hong, Azar, Dimitri T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980686/
https://www.ncbi.nlm.nih.gov/pubmed/35392370
http://dx.doi.org/10.3389/fphys.2022.846936
_version_ 1784681451901419520
author Masood, Faisal
Bhattaram, Rohan
Rosenblatt, Mark I.
Kazlauskas, Andrius
Chang, Jin-Hong
Azar, Dimitri T.
author_facet Masood, Faisal
Bhattaram, Rohan
Rosenblatt, Mark I.
Kazlauskas, Andrius
Chang, Jin-Hong
Azar, Dimitri T.
author_sort Masood, Faisal
collection PubMed
description Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. While some pathologies are exacerbated by lymphatic vessel regression and dysfunction, induced lymphatic regression could be therapeutically beneficial in others. Despite its importance, our understanding of lymphatic vessel regression is far behind that of blood vessel regression. Herein, we review the current understanding of blood vessel regression to identify several hallmarks of this phenomenon that can be extended to further our understanding of lymphatic vessel regression. We also summarize current research on lymphatic vessel regression and an array of research tools and models that can be utilized to advance this field. Additionally, we discuss the roles of lymphatic vessel regression and dysfunction in select pathologies, highlighting how an improved understanding of lymphatic vessel regression may yield therapeutic insights for these disease states.
format Online
Article
Text
id pubmed-8980686
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89806862022-04-06 Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression Masood, Faisal Bhattaram, Rohan Rosenblatt, Mark I. Kazlauskas, Andrius Chang, Jin-Hong Azar, Dimitri T. Front Physiol Physiology Aberrant lymphatic system function has been increasingly implicated in pathologies such as lymphedema, organ transplant rejection, cardiovascular disease, obesity, and neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. While some pathologies are exacerbated by lymphatic vessel regression and dysfunction, induced lymphatic regression could be therapeutically beneficial in others. Despite its importance, our understanding of lymphatic vessel regression is far behind that of blood vessel regression. Herein, we review the current understanding of blood vessel regression to identify several hallmarks of this phenomenon that can be extended to further our understanding of lymphatic vessel regression. We also summarize current research on lymphatic vessel regression and an array of research tools and models that can be utilized to advance this field. Additionally, we discuss the roles of lymphatic vessel regression and dysfunction in select pathologies, highlighting how an improved understanding of lymphatic vessel regression may yield therapeutic insights for these disease states. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8980686/ /pubmed/35392370 http://dx.doi.org/10.3389/fphys.2022.846936 Text en Copyright © 2022 Masood, Bhattaram, Rosenblatt, Kazlauskas, Chang and Azar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Masood, Faisal
Bhattaram, Rohan
Rosenblatt, Mark I.
Kazlauskas, Andrius
Chang, Jin-Hong
Azar, Dimitri T.
Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
title Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
title_full Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
title_fullStr Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
title_full_unstemmed Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
title_short Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression
title_sort lymphatic vessel regression and its therapeutic applications: learning from principles of blood vessel regression
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980686/
https://www.ncbi.nlm.nih.gov/pubmed/35392370
http://dx.doi.org/10.3389/fphys.2022.846936
work_keys_str_mv AT masoodfaisal lymphaticvesselregressionanditstherapeuticapplicationslearningfromprinciplesofbloodvesselregression
AT bhattaramrohan lymphaticvesselregressionanditstherapeuticapplicationslearningfromprinciplesofbloodvesselregression
AT rosenblattmarki lymphaticvesselregressionanditstherapeuticapplicationslearningfromprinciplesofbloodvesselregression
AT kazlauskasandrius lymphaticvesselregressionanditstherapeuticapplicationslearningfromprinciplesofbloodvesselregression
AT changjinhong lymphaticvesselregressionanditstherapeuticapplicationslearningfromprinciplesofbloodvesselregression
AT azardimitrit lymphaticvesselregressionanditstherapeuticapplicationslearningfromprinciplesofbloodvesselregression