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Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats

The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing molecular convergence analyses between ancestral...

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Autores principales: Liu, Zhen, Chen, Peng, Xu, Dong-Ming, Qi, Fei-Yan, Guo, Yuan-Ting, Liu, Qi, Bai, Jing, Zhou, Xin, Shi, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980745/
https://www.ncbi.nlm.nih.gov/pubmed/35391832
http://dx.doi.org/10.1016/j.isci.2022.104114
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author Liu, Zhen
Chen, Peng
Xu, Dong-Ming
Qi, Fei-Yan
Guo, Yuan-Ting
Liu, Qi
Bai, Jing
Zhou, Xin
Shi, Peng
author_facet Liu, Zhen
Chen, Peng
Xu, Dong-Ming
Qi, Fei-Yan
Guo, Yuan-Ting
Liu, Qi
Bai, Jing
Zhou, Xin
Shi, Peng
author_sort Liu, Zhen
collection PubMed
description The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing molecular convergence analyses between ancestral branches of bats and toothed whales. Compared with controls, the molecular convergences were enriched in hearing-related genes for the last common ancestor of bats (LCAB) and extant echolocating bats, but not for the LCA of Old World fruit bats (LCAP). And the convergent hearing gene prestin of the LCAB and the extant echolocating bats functionally converged. More importantly, the high-frequency hearing of the LCAP-prestin knock-in mice decreased with lower cochlear outer hair cell function compared with the LCAB-prestin knock-in mice. Together, our findings provide multiple lines of evidence suggesting a single origin of laryngeal echolocation in the LCAB and the subsequent loss in the LCAP.
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spelling pubmed-89807452022-04-06 Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats Liu, Zhen Chen, Peng Xu, Dong-Ming Qi, Fei-Yan Guo, Yuan-Ting Liu, Qi Bai, Jing Zhou, Xin Shi, Peng iScience Article The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing molecular convergence analyses between ancestral branches of bats and toothed whales. Compared with controls, the molecular convergences were enriched in hearing-related genes for the last common ancestor of bats (LCAB) and extant echolocating bats, but not for the LCA of Old World fruit bats (LCAP). And the convergent hearing gene prestin of the LCAB and the extant echolocating bats functionally converged. More importantly, the high-frequency hearing of the LCAP-prestin knock-in mice decreased with lower cochlear outer hair cell function compared with the LCAB-prestin knock-in mice. Together, our findings provide multiple lines of evidence suggesting a single origin of laryngeal echolocation in the LCAB and the subsequent loss in the LCAP. Elsevier 2022-03-18 /pmc/articles/PMC8980745/ /pubmed/35391832 http://dx.doi.org/10.1016/j.isci.2022.104114 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Liu, Zhen
Chen, Peng
Xu, Dong-Ming
Qi, Fei-Yan
Guo, Yuan-Ting
Liu, Qi
Bai, Jing
Zhou, Xin
Shi, Peng
Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
title Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
title_full Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
title_fullStr Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
title_full_unstemmed Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
title_short Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
title_sort molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980745/
https://www.ncbi.nlm.nih.gov/pubmed/35391832
http://dx.doi.org/10.1016/j.isci.2022.104114
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