Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs

A subset of eukaryotic tRNAs is methylated in the anticodon loop, forming 3-methylcytosine (m(3)C) modifications. In mammals, the number of tRNAs containing m(3)C modifications has been expanded to include mitochondrial (mt) tRNA-Ser-UGA and mt-tRNA-Thr-UGU. However, whereas the enzymes catalyzing m...

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Detalles Bibliográficos
Autores principales: Lentini, Jenna M., Bargabos, Rachel, Chen, Chen, Fu, Dragony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980813/
https://www.ncbi.nlm.nih.gov/pubmed/35247384
http://dx.doi.org/10.1016/j.jbc.2022.101788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980813/
https://www.ncbi.nlm.nih.gov/pubmed/35247384
http://dx.doi.org/10.1016/j.jbc.2022.101788

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