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Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

There are a plethora of cancer causes and the road to fully understanding the carcinogenesis process remains a dream that keeps changing. However, a list of role players that are implicated in the carcinogens process is getting lengthier. Cholesterol is known as bad sterol that is heavily linked wit...

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Autores principales: Laka, Kagiso, Makgoo, Lilian, Mbita, Zukile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981032/
https://www.ncbi.nlm.nih.gov/pubmed/35391801
http://dx.doi.org/10.3389/fgene.2022.841639
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author Laka, Kagiso
Makgoo, Lilian
Mbita, Zukile
author_facet Laka, Kagiso
Makgoo, Lilian
Mbita, Zukile
author_sort Laka, Kagiso
collection PubMed
description There are a plethora of cancer causes and the road to fully understanding the carcinogenesis process remains a dream that keeps changing. However, a list of role players that are implicated in the carcinogens process is getting lengthier. Cholesterol is known as bad sterol that is heavily linked with cardiovascular diseases; however, it is also comprehensively associated with carcinogenesis. There is an extensive list of strategies that have been used to lower cholesterol; nevertheless, the need to find better and effective strategies remains vastly important. The role played by cholesterol in the induction of the carcinogenesis process has attracted huge interest in recent years. Phytochemicals can be dubbed as magic tramp cards that humans could exploit for lowering cancer-causing cholesterol. Additionally, the mechanisms that are regulated by phytochemicals can be targeted for anticancer drug development. One of the key role players in cancer development and suppression, Tumour Protein 53 (TP53), is crucial in regulating the biogenesis of cholesterol and is targeted by several phytochemicals. This minireview covers the role of p53 in the mevalonate pathway and how bioactive phytochemicals target the mevalonate pathway and promote p53-dependent anticancer activities.
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spelling pubmed-89810322022-04-06 Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions Laka, Kagiso Makgoo, Lilian Mbita, Zukile Front Genet Genetics There are a plethora of cancer causes and the road to fully understanding the carcinogenesis process remains a dream that keeps changing. However, a list of role players that are implicated in the carcinogens process is getting lengthier. Cholesterol is known as bad sterol that is heavily linked with cardiovascular diseases; however, it is also comprehensively associated with carcinogenesis. There is an extensive list of strategies that have been used to lower cholesterol; nevertheless, the need to find better and effective strategies remains vastly important. The role played by cholesterol in the induction of the carcinogenesis process has attracted huge interest in recent years. Phytochemicals can be dubbed as magic tramp cards that humans could exploit for lowering cancer-causing cholesterol. Additionally, the mechanisms that are regulated by phytochemicals can be targeted for anticancer drug development. One of the key role players in cancer development and suppression, Tumour Protein 53 (TP53), is crucial in regulating the biogenesis of cholesterol and is targeted by several phytochemicals. This minireview covers the role of p53 in the mevalonate pathway and how bioactive phytochemicals target the mevalonate pathway and promote p53-dependent anticancer activities. Frontiers Media S.A. 2022-03-22 /pmc/articles/PMC8981032/ /pubmed/35391801 http://dx.doi.org/10.3389/fgene.2022.841639 Text en Copyright © 2022 Laka, Makgoo and Mbita. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Laka, Kagiso
Makgoo, Lilian
Mbita, Zukile
Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
title Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
title_full Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
title_fullStr Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
title_full_unstemmed Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
title_short Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions
title_sort cholesterol-lowering phytochemicals: targeting the mevalonate pathway for anticancer interventions
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981032/
https://www.ncbi.nlm.nih.gov/pubmed/35391801
http://dx.doi.org/10.3389/fgene.2022.841639
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